Basic Research

  • Yoshiro Maru


The word <oncogene> sounds a little bit quaint these days. However, we should bear in mind how BCR-ABL was discovered (see Table  9.1 in Chap.  9). The golden marker Ph in CML is indeed the place where the BCR-ABL oncogene is generated. Tumors in animals were known in the past including Rous sarcoma in chicken discovered by Peyton Rous in 1911 that is transmissible from chicken to chicken by RS retrovirus, Yoshida sarcoma in albino rat discovered by Tomizo Yoshida in 1944 that was chemically induced [1, 2]. Howard Temin showed in 1958 that morphological transformation of chicken fibroblasts by RSV was quantitated in a focus-forming assay, which eventually led to the discovery of reverse transcriptase under his persistent hypothesis that the transformation is mediated by a RSV-dependent DNA intermediate, namely DNA provirus, stabilized in the transformed cells [3]. We should consider the fact that acute viral infection is a self-limited process for propagation of virus but persistent transformation of the infected cells needs to have some stable alterations pertinent to the cells.


Reactive Oxygen Species Androgen Receptor Nucleotide Excision Repair Glycolysis Pathway Fumarate Hydratase 


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Copyright information

© Springer Japan 2016

Authors and Affiliations

  • Yoshiro Maru
    • 1
  1. 1.Department of PharmacologyTokyo Women’s Medical UniversityTokyoJapan

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