Currently, the definition of “inflammation” is ambiguous. In ancient medicine, a tumor may be distinguished between inflammatory or neoplastic from the pathological standpoint. When you look at recent scientific literatures, even if the title contains the word “inflammation,” the actual story of the paper is the gene expression analysis of a group of chemokines. This means that “chemokine” is just representing a concept: “inflammation.” Originally, chemokines are growth factors that can stimulate leukocyte mobilization. We currently understand that most of the vascular permeability factors have the chemokine feature at the same time. I believe and therefore propose that it can be safely said that leukocyte mobilization and/or vasopermeability is necessary and sufficient for inflammation. Chapter 1 focuses on this issue.
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