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Dectin-2 in Antimicrobial Immunity and Homeostasis

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C-Type Lectin Receptors in Immunity

Abstract

Dendritic cell-associated lectin-2 (Dectin-2) is one of the most well-characterized members of the C-type lectin family. Recent studies have revealed its indispensable functions as a pattern recognition receptor (PRR) for a wide variety of pathogens, including fungi, bacteria, and viruses. This receptor recognizes microbial carbohydrates as a pathogen-associated molecular pattern (PAMP). Upon ligand ligation, Dectin-2 induces secretion of the pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and TNF, as well as the inhibitory cytokine IL-10. These cytokines differentiate T cells into IL-17-producing Th17 cells to eliminate pathogens. In addition to microbes, Dectin-2 also binds to allergens such as those of house dust mites and helminths to activate the NLRP3 inflammasome. In vivo, Dectin-2 plays a key role in antimicrobial infection, especially antifungal infections. Owing to these abilities, Dectin-2 agonists could be promising adjuvants in vaccinations. In this section, we summarize the current knowledge of Dectin-2 in detail, describing its structure, ligand recognition, signaling, and associated human diseases.

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Authors and Affiliations

  1. Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba City, Chiba, 260-8673, Japan

    Rikio Yabe & Shinobu Saijo

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  1. Rikio Yabe
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  2. Shinobu Saijo
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Correspondence to Shinobu Saijo .

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Editors and Affiliations

  1. Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    Sho Yamasaki

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Yabe, R., Saijo, S. (2016). Dectin-2 in Antimicrobial Immunity and Homeostasis. In: Yamasaki, S. (eds) C-Type Lectin Receptors in Immunity. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56015-9_1

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