Abstract
Reduced cardiac MIBG uptake is caused by the degeneration of the cardiac sympathetic nerve. It is observed in Lewy body disease, Parkinson’s disease (PD) associated with an α-synuclein mutation, PD associated with an α-synuclein multiplication, some cases of PD associated with LRRK2 mutations with Lewy bodies in the brain, and various disorders with Lewy body disease or incidental Lewy body disease (iLBD), in which Lewy bodies are found in the brain. In contrast, cardiac MIBG uptake is usually normal in neurodegenerative parkinsonism and dementia, except for Lewy body disease in which Lewy bodies are not found in the brain. In neurodegenerative disorders and familial PD, degeneration of the cardiac sympathetic nerve is closely related to the presence of Lewy bodies. Therefore, we hypothesize that reduced cardiac MIBG uptake is a potential biomarker for the presence of Lewy bodies. MIBG cardiac scintigraphy allows us to estimate the presence of Lewy bodies.
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Yoshida M, Fukumoto Y, Kuroda Y, Ohkoshi N. Sympathetic denervation of myocardium demonstrated by 123I-MIBG scintigraphy in pure progressive autonomic failure. Eur Neurol. 1997;38:291–6.
Yoshita M. Differentiation of idiopathic Parkinson’s disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy. J Neurol Sci. 1998;155:60–7.
Orimo S, Ozawa E, Nakade S, Sugimoto T, Mizusawa H. 123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;67:189–94.
Braune S, Reinhardt M, Schnitzer R, Riedel A, Lücking CH. Cardiac uptake of [123I]MIBG separates Parkinson’s disease from multiple system atrophy. Neurology. 1999;53:1020–5.
Taki J, Nakajima K, Hwang E-H, Matsunari I, Komai K, Yoshita M, et al. Peripheral sympathetic dysfunction in patients with Parkinson’s disease without autonomic failure is heart selective and disease specific. Eur J Nucl Med. 2000;27:566–73.
Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, et al. Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer disease. J Neurol Neurosurg Psychiatry. 2001;70:781–3.
Yoshita M, Taki J, Yamada M. A clinical role for[123I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer’s-type and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2001;71:583–8.
Mitamoto T, Miyamoto M, Iwanami M, Hirata K. Cardiac 123I-MIBG accumulation in Parkinson’s disease differs in association with REM sleep behavior disorder. Parkinsonism Relat Disord. 2011;17:219–20.
Tijero B, Gómez-Esteban JC, Lezcano E, Fernández-González C, Somme J, Llorens V, et al. Cardiac sympathetic denervation in symptomatic and asymptomatic carriers of the E46K mutation in the α synuclein gene. Parkinsonism Relat Disord. 2013;19:95–100.
Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, et al. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson’s disease. Ann Neurol. 2006;59:298–309.
Hasagawa K, Stoessl AJ, Yokoyama Y, Kowa H, Wszolex ZK, Yoshita S. Familial Parkinsonism: study of original Sagamihara PARK8 (I2020T) Kindred with variable clinicopathologic outcomes. Parkinsonism Relat Disord. 2009;15:300–6.
Nagayama H, Yamazaki M, Ueda M, Nishiyama Y, Hamamoto M, Katayama Y, et al. Low myocardial MIBG uptake in multiple system atrophy with incidental Lewy body pathology: an autopsy case report. Mov Disord. 2008;23:1055–7.
Mori K, Iwasaki Y, Ito M, Mimuro M, Yoshida M. Decreased myocardial uptake of meta-iodobenzylguanidine in an autopsy-confirmed case of corticobasal degeneration with Lewy bodies restricted to the sympathetic ganglia. Clin Neurol. 2012;52:405–10 (in Japanese).
Orimo S, Oka T, Miura H, Tsuchiya K, Mori F, Wakabayashi K, et al. Sympathetic cardiac denervation in Parkinson’s disease and pure autonomic failure but not in multiple system atrophy. J Neurol Neurosurg Psychiatry. 2002;73:776–7.
Orimo S, Ozawa E, Nakade S, Hattori H, Tsuchiya K, Taki K, et al. [123I] meta-iodobenzylguanidine myocardial scintigraphy differentiates corticobasal degeneration from Parkinson’s disease. Intern Med. 2003;42:127–8.
Orimo S, Amino T, Ito Y, Takahashi A, Kojo T, Uchihara T, et al. Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol. 2005;109:583–8.
Orimo S, Amino T, Yokochi M, Kojo T, Uchihara T, Takahashi T, et al. Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2. Mov Disord. 2005;20:1350–3.
Orimo S, Uchihara T, Nakamura A, Mori F, Ikeuchi T, Onodera O, et al. Acta Neuropathol. 2008;116:575–7.
Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson’s disease. Brain Pathol. 2007;17:24–30.
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Orimo, S. (2017). Clinical Implications of Reduced Cardiac MIBG Uptake. In: Iwase, S., Hayano, J., Orimo, S. (eds) Clinical Assessment of the Autonomic Nervous System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56012-8_19
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DOI: https://doi.org/10.1007/978-4-431-56012-8_19
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