Abstract
Behavioral and psychological symptoms of dementia (BPSD) are observed in all forms of dementia. We discuss representative forms of BPSD such as hallucination and delusion, depression, and rapid eye movement (REM) sleep behavior disorder (RBD) observed in patients with dementia with Lewy bodies (DLB). The most representative BPSD for DLB is visual hallucination. McKeith et al. reported that 80 % of DLB cases involved visual hallucination. Delusions occur more frequently in DLB, compared with Alzheimer’s disease (AD). These in the patients with DLB are characterized by delusional misidentification either as a continuation of visual hallucinations or related to delusions resulting from visual misidentification of places, people, or surroundings. Depression is one of the first symptoms of DLB and is listed in the CDLB guidelines as one of the supportive features. One suggestive sign of DLB is rapid eye movement (REM) sleep behavior disorder (RBD), which is significantly more common in the patients with DLB than other forms of neurodegenerative dementia. RBD also occurs earlier than cognitive dysfunction and primary core symptoms such as parkinsonism and visual hallucination.
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Reisberg B, Franssen E, Sclan SG, et al. Stage-specific incidence of potentially remediable behavioral symptoms in aging and Alzheimer’s disease: a study of 120 patients using the BEHAVE-AD. Bull Clin Neurosci. 1989;54:95–112.
McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies third report of the DLB consortium. Neurology. 2005;65:1863–72.
McKeith I, Fairbairn A, Perry R, et al. Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ. 1992;305:673–8.
Harding AJ, Broe GA, Halliday GM, et al. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain. 2002;125:391–403.
Yamamoto E, Iseki E, Murayama N, et al. Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies. Neurosci Lett. 2007;415:219–24.
Nagahama Y, Okina T, Suzuki N, et al. Neural correlates of psychotic symptoms in dementia Lewy bodies. Brain. 2010;133:557–67.
McKeith I, Del Ser T, Spano P, et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet. 2000;356:2031–6.
Ballard C, Holmes C, McKeith I, et al. Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer’s disease. Am J Psychiatry. 1999;156:1039–45.
Ellis HD, Lewis MB. Capgras delusion: a window on face recognition. Trends Cogn Sci. 2001;5:149–56.
Collerton D, Burn D, McKeith I, et al. Systematic review and meta-analysis show that dementia Lewy bodies is a visual-perceptual and attentional-executive dementia. Dement Geriatr Cogn Disord. 2003;16:229–37.
Nagahama Y, Okina T, Suzuki N, et al. Neural correlates of psychotic symptoms in dementia with Lewy bodies. Brain. 2010;133:557–67.
Fujishiro H, Iseki E, Nakamura S, et al. Dementia with Lewy bodies: early diagnostic challenges. Psychogeriatry. 2013;13:123–38.
Simard M, van Reekum R, Cohen T, et al. A review of the cognitive and behavioral symptoms in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci. 2000;12:425–50.
Geser F, Wenning GK, Poewe W, et al. How to diagnose dementia with Lewy bodies: state of the art. Mov Disord. 2005;20:11–20.
Frisina PG, Haroutunian V, Libow IS. The neuropathological basis for depression in Parkinson’s disease. Parkinsonism Relat Disord. 2009;15:144–8.
Mentis MJ, McIntosh AR, Perrine K, et al. Relationships among the metabolic patterns that correlate with mnemonic, visuospatial, and mood symptoms in Parkinson’s disease. Am J Psychiatry. 2002;159:746–54.
Remy P, Doder M, Lees A, et al. Depression in Parkinson’s disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005;128:1314–22.
Sharp SI, Ballard CG, Ziabreva I, et al. Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Pakinson’s disease dementia. Dement Geriatr Cogn Disord. 2008;26:330–8.
Kosaka K, Oyanagi S, Matsushita M, et al. Presenile dementia with Alzheimer-, Pick- and Lewy-body changes. Acta Neuropathol. 1976;36:221–33.
Kosaka K, Yoshimura M, Ikeda K, et al. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree–a new disease? Clin Neuropathol. 1984;3:185–92.
Honda K, Hashimoto M, Yatabe Y, et al. The usefulness of monitoring sleep talking for the diagnosis of dementia with Lewy bodies. Int Psychogeriatr. 2013;25:851–8.
Boeve BF, Silber MH, Ferman TJ, et al. REM sleep behavior disorder in Parkinson’s disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol. 2004;17:146–57.
Boeve BF, Silber MH, Parisi JE, et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology. 2003;61:40–5.
Boeve BF, Silber MH, Ferman TJ, et al. Clinicopathological correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med. 2013;14:754–62.
Murray ME, Ferman TJ, Boeve BF, et al. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology. 2013;81:1681–9.
Stiasny-Kolster K, Mayer G, Schafer S, et al. The REM sleep behavior disorder screening questionnaire—a new diagnostic instrument. Mov Disord. 2007;22:2386–93.
Honda K, Hashimoto M, Yatabe Y, et al. The usefulness of monitoring sleep talking for the diagnosis of Dementia with Lewy bodies. Int Psychogeriatr. 2013;25:851–8.
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Manabe, Y., Kosaka, K. (2017). Behavioral and Psychological Symptoms of Dementia. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_7
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DOI: https://doi.org/10.1007/978-4-431-55948-1_7
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