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Epidemiological Study on Dementia with Lewy Bodies

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Dementia with Lewy Bodies

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Abstract

Lewy bodies are the hallmark of the brainstem pathology of Parkinson’s disease. Dementia with Lewy bodies (DLB) is a common degenerative dementing illness characterized by visual hallucination, fluctuation of cognitive function and consciousness, and REM-related behavior disorder. With the spread of the disease entity of DLB, the reported prevalence has been increasing; however, its accurate prevalence and incidence remains uncertain. In this chapter, we review the previous studies which reported the prevalence and incidence for DLB using the data from community and secondary care setting. As a result, DLB accounts for more than 4 % of all dementia cases, and the incidence of DLB is around 4 % of new dementia cases. However, with more widespread recognition of the clinicopathological entity of DLB, the values of its prevalence and incidence have recently been increasing. Although the consensus clinical criteria for DLB have been revised, its sensitivity remains lower. On the other hand, the results of pathological examination from a cohort study showed much higher prevalence of DLB. In the future, effort should be indispensable to dissipate the discrepancy between clinical and pathological diagnosis of DLB.

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References

  1. Kosaka K, Yoshimura M, Ikeda K, et al. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree–a new disease? Clin Neuropathol. 1984;3:185–92.

    CAS  PubMed  Google Scholar 

  2. Gibb WR, Esiri MM, Lees AJ. Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia). Brain. 1987;110:1131–53.

    Article  PubMed  Google Scholar 

  3. Perry RH, Irving D, Blessed G, et al. Senile dementia of Lewy body type and spectrum of Lewy body disease. Lancet. 1989;1(8646):1088.

    Article  CAS  PubMed  Google Scholar 

  4. Palmqvist S, Hansson O, Minthon L, et al. Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer’s disease with common cognitive tests. Int J Geriatr Psychiatry. 2009;24:1405–12.

    Article  PubMed  Google Scholar 

  5. Zaccai J, McCracken C, Brayne C. A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing. 2005;34:561–6.

    Article  PubMed  Google Scholar 

  6. Van Jones SA, O’Brien JT. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psycol Med. 2014;44:673–83.

    Article  Google Scholar 

  7. Yamada T, Hattori H, Miura A, et al. Prevalence of Alzheimer’s disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci. 2001;55:21–5.

    Article  CAS  PubMed  Google Scholar 

  8. Yamada T, Kadekaru H, Matsumoto S, et al. Prevalence of dementia in the older Japanese-Brazilian population. Psychiatry Clin Neurosci. 2002;56:71–5.

    Article  PubMed  Google Scholar 

  9. Herrera Jr E, Caramelli P, Silveira AS, et al. Epidemiologic survey of dementia in a community-dwelling Brazilian population. Alzheimer Dis Assoc Disord. 2002;56:71–5.

    Google Scholar 

  10. Stevens T, Livingston G, Kitchen G, et al. Islington study on dementia subtypes in the community. Br J Psychiatry. 2002;180:270–6.

    Article  PubMed  Google Scholar 

  11. de Silvia HA, Gunatilake SB, Smith AD, et al. Prevalence of dementia in a semi-urban population in Sri Lanka: report from a regional survey. Int J Geriatr Psychiatry. 2003;18:711–5.

    Article  Google Scholar 

  12. Rahkonen T, Eloniemi-Sulkava U, Rissanen S, et al. Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older. I Neurol Neurosurg Psychiatry. 2003;74:720–4.

    Article  CAS  Google Scholar 

  13. Miech RA, Breitner JCS, Zandi PP, et al. Incidence of AD may decline in the early 90s for men, later for women. The Cache County study. Neurology. 2002;58:209–18.

    Article  CAS  PubMed  Google Scholar 

  14. McKeith IG, Galasko D, Wilcock GK, et al. Lewy body dementia-diagnosis and treatment. Br J Psychiatry. 1995;67:09–717.

    Google Scholar 

  15. McKeith IG, Glasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47:1113–24.

    Article  CAS  PubMed  Google Scholar 

  16. Ikeda M, Hokoishi K, Maki N, et al. Increased prevalence of dementia in Japan: a community-based epidemiological study. Neurology. 2001;57:839–44.

    Article  CAS  PubMed  Google Scholar 

  17. Tognoni G, Ceravolo R, Nucciarone B, et al. From mild cognitive impairment to dementia: a prevalence study in a district of Tuscany, Italy. Acta Neurol Scand. 2005;112:65–71.

    Article  CAS  PubMed  Google Scholar 

  18. Galasko D, Salmon D, Gamst A, et al. Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE. Neurology. 2007;68:1772–81.

    Article  CAS  PubMed  Google Scholar 

  19. Molero AE, Pino-Ramirez G, Maestre GE. High prevalence of dementia in Caribbean population. Neuroepidemiology. 2007;29:107–12.

    Article  PubMed  Google Scholar 

  20. Fernandez Martinez M, CastroFlores J, Perez de las Heras S, et al. Prevalence of neuropsychiatric symptoms in elderly patients with dementia in Mungialde County. Dement Geriatr Cogn Disord. 2008;25:103–8.

    Article  PubMed  Google Scholar 

  21. Gascon-Bayarri J, Rene R, Del Barrion JL, et al. Prevalence of dementia subtypes in EI Prat de Llobregat, Catalonia, Spain: the PRATICON study. Neuroepidemiology. 2007;28:224–34.

    Article  CAS  PubMed  Google Scholar 

  22. Jhoo JH, Kim KW, Huh Y, et al. Prevalence of dementia and its subtypes in an elderly urban Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Dement Geriatr Cogn Disord. 2008;26:270–6.

    Article  PubMed  Google Scholar 

  23. Gurvit H, Emre M, Tinaz S, et al. The prevalence of dementia in an urban Turkish population. Am J Alzheimers Dis Other Demen. 2008;23:67–76.

    Article  CAS  PubMed  Google Scholar 

  24. Arslantas D, Oezbabalik D, Metintas S, et al. Prevalence of dementia and associated risk factors in Middle Anatolia, Turkey. J Clin Neurosci. 2009;16:1455–9.

    Article  PubMed  Google Scholar 

  25. Kim KW, Park JH, Kim M-H, et al. A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea. J Alzheimer Dis. 2011;23:279–89.

    Google Scholar 

  26. Yusuf AJ, Baiyewu O, Sheikh TL, et al. Prevalence of dementia and dementia subtypes among community-dwelling elderly people in northern Nigeria. Int Psychogeriatrics. 2011;23:379–86.

    Article  Google Scholar 

  27. Dimitrov I, Tzourio C, Milanov I, et al. Prevalence of dementia and mild cognitive impairment in a Bulgarian urban population. Am J Alzheimers Dis Other Demen. 2012;27:131–5.

    Article  PubMed  Google Scholar 

  28. Matsui Y, Tanizaki Y, Arima H, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study. J Neurol Neurosurg Psychiatry. 2009;80:366–70.

    Article  CAS  PubMed  Google Scholar 

  29. Perez F, Helmer C, Dartigues JF, et al. A 15-year population-based cohort study of the incidence of Parkinson’s disease and dementia with Lewy bodies in an elderly French cohort. J Neurol Neurosurg Psychiatry. 2010;81:742–6.

    Article  CAS  PubMed  Google Scholar 

  30. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863–72.

    Article  CAS  PubMed  Google Scholar 

  31. Wada-Isoe K, UemuraY SY, et al. Prevalence of dementia in the rural island town of Ama-cho, Japan. Neuroepidemiology. 2009;32:101–6.

    Article  PubMed  Google Scholar 

  32. Tola-Arribas MA, Yugueros MI, Garea MJ, et al. Prevalence of dementia and subtypes in Valladolid, northwestern Spain: the DEMINVALL study. PLoS One. 2013;8(10):e77688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Savica R, Grossardt BR, Bower JH, et al. Incidence of dementia with Lewy bodies and Parkinson disease dementia. JAMA Neurol. 2013;70:1396–402.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Fujimi K, Sasaki K, Noda K, et al. Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study. Brain Pathol. 2008;18:317–25.

    Article  PubMed  Google Scholar 

  35. Litvan I, Bhatia KP, Burn DJ, et al. SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord. 2003;18:467–86.

    Article  PubMed  Google Scholar 

  36. Ferman T, Smith GE, Boeve BF, et al. DLB fluctuations: specific features that reliably differentiate from AD and normal aging. Neurology. 2004;62:181–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

    Takashi Asada

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  1. Takashi Asada
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Correspondence to Takashi Asada .

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Editors and Affiliations

  1. Yokohama City University, Yokohama, Kanagawa, Japan

    Kenji Kosaka

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Asada, T. (2017). Epidemiological Study on Dementia with Lewy Bodies. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_2

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  • DOI: https://doi.org/10.1007/978-4-431-55948-1_2

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55946-7

  • Online ISBN: 978-4-431-55948-1

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