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Glycosignals in Cancer: Mechanisms of Malignant Phenotypes pp 111–124Cite as

Function of Unique O-Glycan Structures in Protecting Gastric Mucosa Against Helicobacter pylori Infection and Gastric Cancer Development

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Abstract

Gastric gland mucin secreted from gland mucous cells located in lower portions of the gastric mucosa contains unique O-linked oligosaccharides displaying terminal α1,4-linked N-acetylglucosamine (αGlcNAc). αGlcNAc inhibits growth and motility of Helicobacter pylori, a microbe causing gastric cancer, by inhibiting biosynthesis of its cell wall component cholesteryl-α-D-glucopyranoside. In addition, αGlcNAc serves as a tumor suppressor for gastric differentiated-type adenocarcinoma, and its loss in gastric cancer cells is associated with progression and poor prognosis of patients with this subtype of gastric cancer. This chapter summarizes protective functions of αGlcNAc against gastric cancer development.

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Acknowledgments

I am grateful to all collaborators for their contributions to this research. In particular, I wish to thank Dr. Tsutomu Katsuyama, Emeritus Professor of Shinshu University, Dr. Minoru Fukuda, Professor at the Sanford-Burnham Medical Research Institute, and Dr. Michiko N. Fukuda, Professor at the Sanford-Burnham Medical Research Institute, for their encouragement and collaboration, and Dr. Elise Lamar for editing this manuscript.

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Authors and Affiliations

  1. Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Jun Nakayama

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  1. Jun Nakayama
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Correspondence to Jun Nakayama .

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Editors and Affiliations

  1. Biomedical Sciences, Chubu University, Kasugai, Japan

    Koichi Furukawa

  2. Glycobiology Unit, Sanford-Burnham Med Res Inst, La Jolla, California, USA

    Minoru Fukuda

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Nakayama, J. (2016). Function of Unique O-Glycan Structures in Protecting Gastric Mucosa Against Helicobacter pylori Infection and Gastric Cancer Development. In: Furukawa, K., Fukuda, M. (eds) Glycosignals in Cancer: Mechanisms of Malignant Phenotypes . Springer, Tokyo. https://doi.org/10.1007/978-4-431-55939-9_7

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