Abstract
Polyps of the gastrointestinal tract are mucosal elevations that may have a mechanical, developmental, inflammatory, or neoplastic pathogenesis. Therefore, it is not surprising that there is no specific relationship between gastrointestinal polyps and H. pylori infection. In the stomach, inflammatory and proliferative responses, irrespective of their etiology, seem to favor the development of inflammatory polyps. Intact oxyntic glands, unaffected by inflammatory changes, seem to be more vulnerable to focal dilatations induced by proton pump inhibitors, hence the strong negative association of these nonneoplastic, noninflammatory polyps with H. pylori gastritis. Gastric adenomas, precursors of adenocarcinoma, are likely related to H. pylori infection by the same mechanisms that link this infection to gastric cancer. In the colon, the indisputable association of H. pylori gastritis with both hyperplastic and neoplastic polyps remains largely unexplained.
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References
Abraham SC, Singh VK, Yardley JH, Wu TT (2001) Hyperplastic polyps of the stomach: associations with histologic patterns of gastritis and gastric atrophy. Am J Surg Pathol 25:500–507
Bae RC, Jeon SW, Cho HJ, Jung MK, Kweon YO, Kim SK (2009) Gastric dysplasia may be an independent risk factor of an advanced colorectal neoplasm. World J Gastroenterol 15:5722–5726
Bockus HL (1968) Gastroenterology. Saunders, Philadelphia
Cao H, Qu R, Zhang Z, Kong X, Wang S, Jiang K, Wang B (2014) Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China. Chin Med J (Engl) 127:1239–1243
Carmack SW, Genta RM, Graham DY, Lauwers GY (2009a) Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol 6:331–341
Carmack SW, Genta RM, Schuler CM, Saboorian MH (2009b) The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol 104:1524–1532
Chu S, Schubert ML (2013) Gastric secretion. Curr Opin Gastroenterol 29:636–641
Cockburn AN, Morgan CJ, Genta RM (2013) Neuroendocrine proliferations of the stomach: a pragmatic approach for the perplexed pathologist. Adv Anat Pathol 20:148–157
Correa P, Cuello C, Gordillo G, Zarama G, Lopez J, Haenszel W, Tannenbaum S (1979). The gastric microenvironment in populations at high risk to stomach cancer. Natl Cancer Inst Monogr 53:167–170
Dickey W, Kenny BD, McConnell JB (1996) Prevalence of fundic gland polyps in a western European population. J Clin Gastroenterol 23:73–75
Dirschmid K, Platz-Baudin C, Stolte M (2006) Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa? Virchows Arch 448:80–84
Dixon MF, O’Connor HJ, Axon AT, King RF, Johnston D (1986) Reflux gastritis: distinct histopathological entity? J Clin Pathol 39:524–530
Dixon MF, Genta RM, Yardley JH, Correa P (1996) Classification and grading of gastritis. The updated Sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 20:1161–1181
el-Zimaity HM, Jackson FW, Graham DY (1997) Fundic gland polyps developing during omeprazole therapy. Am J Gastroenterol 92:1858–1860
Elster K (1976) Histologic classification of gastric polyps. Curr Top Pathol 63:77–93
Fujimori S, Kishida T, Kobayashi T, Sekita Y, Seo T, Nagata K, Tatsuguchi A, Gudis K, Yokoi K, Tanaka N, Yamashita K, Tajiri T, Ohaki Y, Sakamoto C (2005) Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. J Gastroenterol 40:887–893
Genta RM, Schuler CM, Robiou CI, Lash RH (2009) No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients. Clin Gastroenterol Hepatol 7:849–854
Genta RM, Kinsey RS, Singhal A, Suterwala S (2010) Gastric foveolar metaplasia and gastric heterotopia in the duodenum: no evidence of an etiologic role for Helicobacter pylori. Hum Pathol 41:1593–1600
Genta RM, Hurrell JM, Sonnenberg A (2014) Duodenal adenomas coincide with colorectal neoplasia. Dig Dis Sci 59:2249–2254
Gotoda T, Saito D, Kondo H, Ono H, Oda I, Fujishiro M, Yamaguchi H (1999) Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori. J Gastroenterol 34(Suppl 11):91–96
Graham DY (2014) Helicobacter pylori eradication and metachronous gastric cancer. Clin Gastroenterol Hepatol 12:801–803
Graham DY, Genta RM (2008) Long-term proton pump inhibitor use and gastrointestinal cancer. Curr Gastroenterol Rep 10:543–547
Han JS, Jang JS, Choi SR, Kwon HC, Kim MC, Jeong JS, Kim SJ, Sohn YJ, Lee EJ (2011) A study of metachronous cancer after endoscopic resection of early gastric cancer. Scand J Gastroenterol 46:1099–1104
Hanada K, Graham DY (2014) Helicobacter pylori and the molecular pathogenesis of intestinal-type gastric carcinoma. Expert Rev Anticancer Ther 14:947–954
Haziri A, Juniku-Shkololli A, Gashi Z, Berisha D, Haziri A (2010) Helicobacter pylori infection and precancerous lesions of the stomach. Med Arh 64:248–249
Hirasaki S, Matsubara M, Ikeda F, Taniguchi H, Suzuki S (2007) Gastric inflammatory fibroid polyp treated with Helicobacter pylori eradication therapy. Intern Med 46:855–858
Inoue K, Fujisawa T, Haruma K (2010) Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies. Int J Biol Markers 25:207–212
Kim HH, Cho EJ, Noh E, Choi SR, Park SJ, Park MI, Moon W (2013) Missed synchronous gastric neoplasm with endoscopic submucosal dissection for gastric neoplasm: experience in our hospital. Dig Endosc 25:32–38
Kishikawa H, Kaida S, Takarabe S, Miyoshi J, Matsukubo T, Miyauchi J, Tanaka Y, Miura S, Nishida J (2014) Fundic gland polyps accurately predict a low risk of future gastric carcinogenesis. Clin Res Hepatol Gastroenterol 38:505–512
Lahner E, Sbrozzi-Vanni A, Vannella L, Corleto VD, di Giulio E, Delle FG, Annibale B (2012) No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia. Dig Liver Dis 44:793–797
Lauwers GY, Srivastava A (2007) Gastric preneoplastic lesions and epithelial dysplasia. Gastroenterol Clin N Am 36:813–829, vi
Lauwers GY, Wahl SJ, Melamed J, Rojas-Corona RR (1993) p53 expression in precancerous gastric lesions: an immunohistochemical study of PAb 1801 monoclonal antibody on adenomatous and hyperplastic gastric polyps. Am J Gastroenterol 88:1916–1919
Lauwers GY, Carneiro F, Graham DY, Curado MP, Franceschi S, Montgomery EA, Tatematsu M, Hattori T (2010) Tumors of the stomach: gastric carcinoma. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification: tumors of the digestive system, 4th edn. IARC, Lyon, pp 48–58
Laxen F (1981) Gastric polyps and gastric carcinoma. Ann Clin Res 13:154–155
Laxen F, Sipponen P, Ihamaki T, Hakkiluoto A, Dortscheva Z (1982) Gastric polyps; their morphological and endoscopical characteristics and relation to gastric carcinoma. Acta Pathol Microbiol Immunol Scand A 90:221–228
Lee IS, Park YS, Kim KC, Kim TH, Kim HS, Choi KD, Lee GH, Yook JH, Oh ST, Kim BS (2012) Multiple synchronous early gastric cancers: high-risk group and proper management. Surg Oncol 21:269–273
Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S (2007) Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study. Helicobacter 12:328–332
Maguilnik I, Neumann WL, Sonnenberg A, Genta RM (2012) Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract. Aliment Pharmacol Ther 36:736–743
Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A (2005) Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer 117:1058–1059
Murakami K, Mitomi H, Yamashita K, Tanabe S, Saigenji K, Okayasu I (2001) p53, but not c-Ki-ras, mutation and down-regulation of p21WAF1/CIP1 and cyclin D1 are associated with malignant transformation in gastric hyperplastic polyps. Am J Clin Pathol 115:224–234
Nakamura T, Nakano G (1985) Histopathological classification and malignant change in gastric polyps. J Clin Pathol 38:754–764
Neumann WL, Coss E, Rugge M, Genta RM (2013) Autoimmune atrophic gastritis – pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol 10:529–541
Nishiyama Y, Koyama S, Andoh A, Kishi Y, Yoshikawa K, Ishizuka I, Yokono T, Fujiyama Y (2003) Gastric inflammatory fibroid polyp treated with Helicobacter pylori eradication therapy. Intern Med 42:263–267
Nogueira AM, Carneiro F, Seruca R, Cirnes L, Veiga I, Machado JC, Sobrinho-Simoes M (1999) Microsatellite instability in hyperplastic and adenomatous polyps of the stomach. Cancer 86:1649–1656
Raghunath AS, O’Morain C, McLoughlin RC (2005) Review article: the long-term use of proton-pump inhibitors. Aliment Pharmacol Ther 22(Suppl 1):55–63, 55–63
Rindi G, Azzoni C, La RS, Klersy C, Paolotti D, Rappel S, Stolte M, Capella C, Bordi C, Solcia E (1999) ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology 116:532–542
Saito K, Arai K, Mori M, Kobayashi R, Ohki I (2000) Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma. Gastrointest Endosc 52:27–32
Sakai N, Tatsuta M, Hirasawa R, Iishi H, Baba M, Yokota Y, Ikeda F (1998) Low prevalence of Helicobacter pylori infection in patients with hamartomatous fundic polyps. Dig Dis Sci 43:766–772
Samarasam I, Roberts-Thomson J, Brockwell D (2009) Gastric fundic gland polyps: a clinico-pathological study from North West Tasmania. ANZ J Surg 79:467–470
Selgrad M, Bornschein J, Kandulski A, Hille C, Weigt J, Roessner A, Wex T, Malfertheiner P (2014) Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms. Int J Cancer 135:1127–1131
Shaib YH, Rugge M, Graham DY, Genta RM (2013) Management of gastric polyps: an endoscopy-based approach. Clin Gastroenterol Hepatol 11:1374–1384
Shand AG, Taylor AC, Banerjee M, Lessels A, Coia J, Clark C, Haites N, Ghosh S (2002) Gastric fundic gland polyps in south-east Scotland: absence of adenomatous polyposis coli gene mutations and a strikingly low prevalence of Helicobacter pylori infection. J Gastroenterol Hepatol 17:1161–1164
Siddheshwar RK, Muhammad KB, Gray JC, Kelly SB (2001) Seroprevalence of Helicobacter pylori in patients with colorectal polyps and colorectal carcinoma. Am J Gastroenterol 96:84–88
Singh P, Sarkar S, Kantara C, Maxwell C (2012) Progastrin peptides increase the risk of developing colonic tumors: impact on colonic stem cells. Curr Colorectal Cancer Rep 8:277–289
Solcia E, Rindi G, Paolotti D, Luinetti O, Klersy C, Zangrandi A, La RS, Capella C (1998) Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors. Yale J Biol Med 71:285–290
Solcia E, Arnold R, Capella C, Klimstra DS, Kloppel G, Komminoth P, Rindi G (2010) Tumours of the stomach: neuroendocrine neoplasms of the stomach. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system, 2nd edn. IARC, Lyon, pp 64–68
Sonnenberg A, Genta RM (2013) Helicobacter pylori is a risk factor for colonic neoplasms. Am J Gastroenterol 108:208–215
Sonnenberg A, Genta RM (2014) Prevalence of benign gastric polyps in a large pathology database. Dig Liver Dis 47(2):164–169
Stolte M, Sticht T, Eidt S, Ebert D, Finkenzeller G (1994) Frequency, location, and age and sex distribution of various types of gastric polyp. Endoscopy 26:659–665
Tazaki S, Nozu F, Yosikawa N, Imawari M, Suzuki N, Tominaga K, Hoshino M, Suzuki S, Hayashi K (2011) Sporadic fundic gland polyp-related adenomas occurred in non-atrophic gastric mucosa without Helicobacter pylori infection. Dig Endosc 23:182–186
Tovey FI, Hobsley M, Kaushik SP, Pandey R, Kurian G, Singh K, Sood A, Jehangir E (2004) Duodenal gastric metaplasia and Helicobacter pylori infection in high and low duodenal ulcer-prevalent areas in India. J Gastroenterol Hepatol 19:497–505
Voutilainen M, Juhola M, Farkkila M, Sipponen P (2003) Gastric metaplasia and chronic inflammation at the duodenal bulb mucosa. Dig Liver Dis 35:94–98
Watanabe N, Seno H, Nakajima T, Yazumi S, Miyamoto S, Matsumoto S, Itoh T, Kawanami C, Okazaki K, Chiba T (2002) Regression of fundic gland polyps following acquisition of Helicobacter pylori. Gut 51:742–745
Yao T, Kajiwara M, Kuroiwa S, Iwashita A, Oya M, Kabashima A, Tsuneyoshi M (2002) Malignant transformation of gastric hyperplastic polyps: alteration of phenotypes, proliferative activity, and p53 expression. Hum Pathol 33:1016–1022
Zhao YS, Wang F, Chang D, Han B, You DY (2008) Meta-analysis of different test indicators: Helicobacter pylori infection and the risk of colorectal cancer. Int J Color Dis 23:875–882
Zumkeller N, Brenner H, Zwahlen M, Rothenbacher D (2006) Helicobacter pylori infection and colorectal cancer risk: a meta-analysis. Helicobacter 11:75–80
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Genta, R.M., Lash, R.H. (2016). Helicobacter pylori and Gastrointestinal Polyps. In: Backert, S., Yamaoka, Y. (eds) Helicobacter pylori Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55936-8_16
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