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Drosophila–Acetobacter as a Model System for Understanding Animal–Microbiota Interactions

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Acetic Acid Bacteria

Abstract

All metazoans harbor a high number of microorganisms in the gut. It is generally accepted that these gut–microbe interactions modulate a diverse range of host physiology, including immunity, development, and metabolism. Analyses using genetically amenable model animals such as Drosophila have provided a key framework to understand the molecular mechanisms underlying gut–microbe interactions. Recent investigations revealed that the acetic acid bacterium is one of the major naturally occurring commensal bacteria in the gut of the Drosophila host. The genetic tools available on both the microbial side and the host side provide a unique opportunity to dissect the complex interactions between gut microbes and their hosts. In this chapter, the role of the Acetobacter microbiome in animal physiology is described.

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Acknowledgments

The authors are supported by grants (NRF-2015R1A3A2033475 to W.-J.L. and NRF-2013R1A1A2013250 to S.-H.K) from National Research Foundation of Korea.

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Authors and Affiliations

  1. School of Biological Science, Seoul National University and National Creative Research Initiative Center for Hologenomics, Seoul National University, Seoul, 151-742, South Korea

    Sung-Hee Kim, Kyung-Ah Lee, Do-Young Park, In-Hwan Jang & Won-Jae Lee

  2. Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151-742, South Korea

    Sung-Hee Kim, Kyung-Ah Lee, Do-Young Park, In-Hwan Jang & Won-Jae Lee

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  1. Sung-Hee Kim
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  2. Kyung-Ah Lee
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  3. Do-Young Park
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  4. In-Hwan Jang
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  5. Won-Jae Lee
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Correspondence to Won-Jae Lee .

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Editors and Affiliations

  1. Department of Biological Chemistry, Facu, Yamaguchi University, Yamaguchi, Japan

    Kazunobu Matsushita

  2. Department of Bioscience and Biotechnolo, University of the Ryukyus, Okinawa, Japan

    Hirohide Toyama

  3. Bio-Fine Research Institute Ajinomoto Co, Kawasaki, Japan

    Naoto Tonouchi

  4. Department of Fermentation Science, Facu, Tokyo University of Agriculture, Tokyo, Japan

    Akiko Okamoto-Kainuma

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Kim, SH., Lee, KA., Park, DY., Jang, IH., Lee, WJ. (2016). Drosophila–Acetobacter as a Model System for Understanding Animal–Microbiota Interactions. In: Matsushita, K., Toyama, H., Tonouchi, N., Okamoto-Kainuma, A. (eds) Acetic Acid Bacteria. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55933-7_6

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