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HSF Regulates Immune and Inflammatory Response

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Heat Shock Factor

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Abstract

Both heat shock response and immune response are fundamental and indispensable systems for biological defense mechanisms. A key part of the heat shock response is the upregulation of heat shock proteins (HSPs), which are virtually found in all living organisms, from bacteria to humans. The induced expression of HSPs during heat shock is generally controlled by a single transcription factor; in mammals this regulation is performed by heat shock factor 1 (HSF1). The primary function of HSPs is to serve as molecular chaperones, involved in the folding and unfolding of other proteins. Recent works indicate that HSPs play important roles in the immune response, including antigen presentation, as well as activation of macrophages, lymphocytes, and dendritic cells. In addition, HSF1 regulates the expression of inflammatory cytokines directly or indirectly. In this chapter, the coordinate regulation of heat shock response and immune and inflammatory response and the involvement of these responses in inflammatory diseases are summarized.

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Acknowledgment

Reiko Akagi, Shoshana Bar-nun, and Amy Azuma are gratefully acknowledged for their help in the preparation of this manuscript. This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and a grant from Yasuda Women’s University.

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  1. Department of Pharmacy, Yasuda Women’s University, 6-13-1, Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan

    Sachiye Inouye

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  1. Department of Biochemistry & Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan

    Akira Nakai

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Inouye, S. (2016). HSF Regulates Immune and Inflammatory Response. In: Nakai, A. (eds) Heat Shock Factor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55852-1_9

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