Abstract
Heat shock response (HSR) is characterized by robust induction of heat shock proteins (HSPs) during heat shock and is regulated mainly at the level of transcription by heat shock factor (HSF). Preexisting inert HSF monomers undergo conformational change to form trimers that bind to DNA and to acquire transcriptional activity during heat shock and other stimuli. These two steps are separated processes and are induced by release from feedback repression by HSPs, direct effects of stimuli, posttranslational modifications, and others. Basal activity of HSF is also regulated in unstressed conditions. In this chapter, we review molecular mechanisms of activation and repression of HSF and describe stimuli that activate HSF by controlling these mechanisms.
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References
Abane R, Mezger V (2010) Roles of heat shock factors in gametogenesis and development. FEBS J 277:4150–4172
Abravaya K, Phillips B, Morimoto RI (1991) Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes Dev 5:2117–2127
Abravaya K, Myers MP, Murphy SP et al (1992) The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev 6:1153–1164
Ahn SG, Thiele DJ (2003) Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. Genes Dev 17:516–528
Akerfelt M, Morimoto RI, Sistonen L (2010) Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol 11:545–555
Ali A, Bharadwaj S, O’Carroll R et al (1998) HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes. Mol Cell Biol 18:4949–4960
Amici C, Sistonen L, Santoro MG et al (1992) Antiproliferative prostaglandins activate heat shock transcription factor. Proc Natl Acad Sci USA 89:6227–6231
Anckar J, Hietakangas V, Denessiouk K et al (2006) Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol Cell Biol 26:955–964
Ashburner M, Bonner JJ (1979) The induction of gene activity in drosophila by heat shock. Cell 17:241–254
Balch WE, Morimoto RI, Dillin A et al (2008) Adapting proteostasis for disease intervention. Science 319:916–919
Baler R, Welch WJ, Voellmy R (1992) Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol 117:1151–1159
Baler R, Dahl G, Voellmy R (1993) Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol 13:2486–2496
Bersuker K, Hipp MS, Calamini B et al (2013) Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease. J Biol Chem 288:23633–23638
Bharadwaj S, Ali A, Ovsenek N (1999) Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 in vivo. Mol Cell Biol 19:8033–8041
Björk JK, Sistonen L (2010) Regulation of the members of the mammalian heat shock factor family. FEBS J 277:4126–4139
Blake MJ, Udelsman R, Feulner GJ et al (1991) Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response. Proc Natl Acad Sci USA 88:9873–9877
Boorstein WR, Craig EA (1990) Transcriptional regulation of SSA3, an HSP70 gene from Saccharomyces cerevisiae. Mol Cell Biol 10:3262–3267
Budzyński MA, Puustinen MC, Joutsen J et al (2015) Uncoupling stress-inducible phosphorylation of heat shock factor 1 from its activation. Mol Cell Biol 35:2530–2540
Chiang WC, Ching TT, Lee HC et al (2012) HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell 148:322–334
Chu B, Soncin F, Price BD et al (1996) Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem 271:30847–30857
Chu B, Zhong R, Soncin F et al (1998) Transcriptional activity of heat shock factor 1 at 37° C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J Biol Chem 273:18640–18646
Chuma M, Sakamoto N, Nakai A et al (2014) Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase. Carcinogenesis 35:272–281
Clos J, Westwood JT, Becker PB et al (1990) Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to a negative regulation. Cell 63:1085–1097
Cotto JJ, Kline M, Morimoto RI (1996) Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem 271:3355–3358
Craig EA, Gross CA (1991) Is hsp70 the cellular thermometer? Trends Biochem Sci 16:135–140
Craig EA, Jacobsen K (1984) Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth. Cell 38:841–849
Dai R, Frejtag W, He B et al (2000) c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. J Biol Chem 275:18210–18218
Dai Q, Zhang C, Wu Y et al (2003) CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J 22:5446–5458
Dai C, Whitesell L, Rogers AB et al (2007) Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130:1005–1018
Dai C, Santagata S, Tang Z et al (2012) Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest 122:3742–3754
Dai S, Tang Z, Cao J et al (2015) Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK. EMBO J 34:275–293
DiDomenico BJ, Bugaisky GE, Lindquist S (1982) The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels. Cell 31:593–603
Duina AA, Kalton HM, Gaber RF (1998) Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response. J Biol Chem 273:18974–18978
Farkas T, Kutskova YA, Zimarino V (1998) Intramolecular repression of mouse heat shock factor 1. Mol Cell Biol 18:906–918
Fawcett TW, Sylvester SL, Sarge KD et al (1994) Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem 269:32272–32278
Fujimoto M, Nakai A (2010) The heat shock factor family and adaptation to proteotoxic stress. FEBS J 277:4112–4125
Fujimoto M, Takaki E, Hayashi T et al (2005) Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J Biol Chem 280:34908–34916
Gallo GJ, Schuetz TJ, Kingston RE (1991) Regulation of heat shock factor in Schizosaccharomyces pombe more closely resembles regulation in mammals than in Saccharomyces cerevisiae. Mol Cell Biol 11:281–288
Ghosh SK, Missra A, Gilmour DS (2011) Negative elongation factor accelerates the rate at which heat shock genes are shut off by facilitating dissociation of heat shock factor. Mol Cell Biol 31:4232–4243
Gidalevitz T, Kikis EA, Morimoto RI (2010) A cellular perspective on conformational disease: the role of genetic background and proteostasis networks. Curr Opin Struct Biol 20:23–32
Goodson ML, Sarge KD (1995) Heat-inducible DNA binding of purified heat shock transcription factor 1. J Biol Chem 270:2447–2450
Goodson ML, Hong Y, Rogers R et al (2001) Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. J Biol Chem 276:18513–18518
Goossens V, Grooten J, De Vos K et al (1995) Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci USA 92:8115–8119
Green M, Schuetz TJ, Sullivan EK et al (1995) A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol 15:3354–3362
Guettouche T, Boellmann F, Lane WS et al (2005) Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem 6:4
Guisbert E, Herman C, Lu CZ et al (2004) A chaperone network controls the heat shock response in E. coli. Genes Dev 18:2812–2821
Guisbert E, Yura T, Rhodius VA et al (2008) Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol Mol Biol Rev 72:545–554
Guo Y, Guettouche T, Fenna M et al (2001) Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem 276:45791–45799
Hargitai J, Lewis H, Boros I et al (2003) Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun 307:689–695
Hayashida N, Fujimoto M, Tan K et al (2010) Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. EMBO J 29:3459–3469
Hensold JO, Hunt CR, Calderwood SK et al (1990) DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol Cell Biol 10:1600–1608
Hietakangas V, Ahlskog JK, Jakobsson AM et al (2003) Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol 23:2953–2968
Hietakangas V, Anckar J, Blomster HA et al (2006) PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci USA 103:45–50
Higashi T, Nakai A, Uemura Y et al (1995) Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock. Brain Res Mol Brain Res 34:262–270
Hipp MS, Park SH, Hartl FU (2014) Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol 24:506–514
Hirakawa T, Rokutan K, Nikawa T et al (1996) Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111:345–357
Hoang AT, Huang J, Rudra-Ganguly N et al (2000) A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma. Am J Pathol 156:857–864
Høj A, Jakobsen BK (1994) A short element required for turning off heat shock transcription factor: evidence that phosphorylation enhances deactivation. EMBO J 13:2617–2624
Holbrook NJ, Carlson SG, Choi AM et al (1992) Induction of HSP70 gene expression by the antiproliferative prostaglandin PGA2: a growth-dependent response mediated by activation of heat shock transcription factor. Mol Cell Biol 12:1528–1534
Holmberg CI, Hietakangas V, Mikhailov A et al (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20:3800–3810
Hong Y, Rogers R, Matunis MJ et al (2001) Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J Biol Chem 276:40263–40267
Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300:1142–1145
Inouye S, Izu H, Takaki E et al (2004) Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem 279:38701–38709
Johnston D, Oppermann H, Jackson J et al (1980) Induction of four proteins in chick embryo cells by sodium arsenite. J Biol Chem 255:6975–6980
Jurivich DA, Sistonen L, Kroes RA et al (1992) Effect of sodium salicylate on the human heat shock response. Science 255:1243–1245
Jurivich DA, Sistonen L, Sarge KD et al (1994) Arachidonate is a potent modulator of human heat shock gene transcription. Proc Natl Acad Sci USA 91:2280–2284
Jurivich DA, Pachetti C, Qiu L et al (1995) Salicylate triggers heat shock factor differently than heat. J Biol Chem 270:24489–24495
Kawazoe Y, Nakai A, Tanabe M et al (1998) Proteasome inhibition leads to the activation of all members of the heat-shock-factor family. Eur J Biochem 255:356–362
Kelley PM, Schlesinger MJ (1978) The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts. Cell 15:1277–1286
Kieran D, Kalmar B, Dick JR et al (2004) Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med 10:402–405
Kim D, Ouyang H, Li GC (1995) Heat shock protein hsp70 accelerates the recovery of heat-shocked mammalian cells through its modulation of heat shock transcription factor HSF1. Proc Natl Acad Sci USA 92:2126–2130
Kim SH, Kim D, Jung GS et al (1999) Involvement of c-Jun NH(2)-terminal kinase pathway in differential regulation of heat shock proteins by anticancer drugs. Biochem Biophys Res Commun 262:516–522
Kim SA, Yoon JH, Lee SH et al (2005) Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. J Biol Chem 280:12653–12657
Kline MP, Morimoto RI (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17:2107–2115
Knauf U, Newton EM, Kyriakis J et al (1996) Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10:2782–2793
Kourtis N, Moubarak RS, Aranda-Orgilles B et al (2015) FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification. Nat Cell Biol 17:322–332
Kroes RA, Abravaya K, Seidenfeld J et al (1991) Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proc Natl Acad Sci USA 88:4825–4829
Larson JS, Schuetz TJ, Kingston RE (1988) Activation in vitro of sequence-specific DNA binding by a human regulatory factor. Nature 335:372–375
Larson JS, Schuetz TJ, Kingston RE (1995) In vitro activation of purified human heat shock factor by heat. Biochemistry 34:1902–1911
Lee BS, Chen J, Angelidis C et al (1995) Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. Proc Natl Acad Sci USA 92:7207–7211
Lee YJ, Kim EH, Lee JS et al (2008) HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. Cancer Res 68:7550–7560
Levinson W, Oppermann H, Jackson J (1980) Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells. Biochim Biophys Acta 606:170–180
Li GC (1983) Induction of thermotolerance and enhanced heat shock protein synthesis in Chinese hamster fibroblasts by sodium arsenite and by ethanol. J Cell Physiol 115:116–122
Li Q, Herrler M, Landsberger N et al (1998) Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO J 17:6300–6315
Lindquist S (1986) The heat-shock response. Annu Rev Biochem 55:1151–1191
Lu M, Kim HE, Li CR et al (2008) Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity. Biochemistry 47:6007–6015
Manalo DJ, Liu AY (2001) Resolution, detection, and characterization of redox conformers of human HSF1. J Biol Chem 276:23554–23561
Manalo DJ, Lin Z, Liu AY (2002) Redox-dependent regulation of the conformation and function of human heat shock factor 1. Biochemistry 41:2580–2588
Marchler G, Wu C (2001) Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1. EMBO J 20:499–509
Mathew A, Mathur SK, Morimoto RI (1998) Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol 18:5091–5098
Mathur SK, Sistonen L, Brown IR et al (1994) Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proc Natl Acad Sci USA 91:8695–8699
Mendillo ML, Santagata S, Koeva M et al (2012) HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 150:549–562
Min JN, Huang L, Zimonjic DB et al (2007) Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene 26:5086–5097
Morimoto RI (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12:3788–3796
Morimoto RI (2011) The heat shock response: systems biology of proteotoxic stress in aging and disease. Cold Spring Harb Symp Quant Biol 76:91–99
Morley JF, Morimoto RI (2004) Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15:657–664
Mosser DD, Kotzbauer PT, Sarge KD et al (1990) In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci USA 87:3748–3752
Mosser DD, Duchaine J, Massie B (1993) The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol Cell Biol 13:5427–5438
Murata S, Chiba T, Tanaka K (2003) CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Int J Biochem Cell Biol 35:572–578
Murshid A, Chou SD, Prince T et al (2010) Protein kinase a binds and activates heat shock factor 1. PLoS One 5:e13830
Nadeau K, Das A, Walsh CT (1993) Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. J Biol Chem 268:1479–1487
Nair SC, Toran EJ, Rimerman RA et al (1996) A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones 1:237–250
Neef DW, Jaeger AM, Gomez-Pastor R et al (2014) A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep 9:955–966
Newton EM, Knauf U, Green M et al (1996) The regulatory domain of human heat shock factor 1 is sufficient to sense heat stress. Mol Cell Biol 16:839–846
Nishizawa J, Nakai A, Higashi T et al (1996) Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart. Circulation 94:2185–2192
Nishizawa J, Nakai A, Matsuda K et al (1999) Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart. Circulation 99:934–941
Otaka M, Yamamoto S, Ogasawara K et al (2007) The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer). Biochem Biophys Res Commun 353:399–404
Pirkkala L, Alastalo TP, Zuo X et al (2000) Disruption of heat shock factor 1 reveals an essential role in the ubiquitin proteolytic pathway. Mol Cell Biol 20:2670–2675
Polla BS, Bachelet M, Elia G et al (1998) Stress proteins in inflammation. Ann NY Acad Sci 851:75–85
Rabindran SK, Wisniewski J, Li L et al (1994) Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo. Mol Cell Biol 14:6552–6560
Raychaudhuri S, Loew C, Körner R et al (2014) Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1. Cell 156:975–985
Raynes R, Pombier KM, Nguyen K et al (2013) The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. PLoS One 8:e54364
Reinke H, Saini C, Fleury-Olela F et al (2008) Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev 22:331–345
Richter K, Haslbeck KM, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40:253–266
Ritossa F (1962) A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia 18:571–573
Santagata S, Hu R, Lin NU et al (2011) High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci USA 108:18378–18383
Santagata S, Xu YM, Wijeratne EM et al (2012) Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol 7:340–349
Santagata S, Mendillo ML, Tang YC et al (2013) Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science 341:1238303
Sarge KD, Zimarino V, Holm K et al (1991) Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev 5:1902–1911
Sarge KD, Murphy SP, Morimoto RI (1993) Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol 13:1392–1407
Schett G, Redlich K, Xu Q et al (1998) Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. J Clin Invest 102:302–311
Shamovsky I, Ivannikov M, Kandel ES (2006) RNA-mediated response to heat shock in mammalian cells. Nature 440:556–560
Shi Y, Mosser DD, Morimoto RI (1998) Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev 12:654–666
Sorger PK, Pelham HR (1988) Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54:855–864
Sorger PK, Lewis MJ, Pelham HR (1987) Heat shock factor is regulated differently in yeast and HeLa cells. Nature 329:81–84
Straus DS, Glass CK (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21:185–210
Straus DB, Walter WA, Gross CA (1989) The activity of sigma 32 is reduced under conditions of excess heat shock protein production in Escherichia coli. Genes Dev 3:2003–2310
Straus D, Walter W, Gross CA (1990) DnaK, DnaJ & GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32. Genes Dev 4:2202–2209
Takaki E, Fujimoto M, Sugahara K et al (2006) Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice. J Biol Chem 281:4931–4937
Takii R, Fujimoto M, Tan K et al (2015) ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol 35:11–25
Tateishi Y, Ariyoshi M, Igarashi R et al (2009) Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. J Biol Chem 284:2435–2447
Tilly K, McKittrick N, Zylicz M et al (1983) The dnaK protein modulates the heat-shock response of Escherichia coli. Cell 34:641–646
Tilly K, Spence J, Georgopoulos C (1989) Modulation of stability of the Escherichia coli heat shock regulatory factor cr32. J Bacteriol 171:1585–1589
Tomoyasu T, Ogura T, Tatsuta T et al (1998) Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli. Mol Microbiol 30:567–581
Trott A, West JD, Klaić L et al (2008) Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell 19:1104–1112
Vera M, Pani B, Griffiths LA et al (2014) The translation elongation factor eEF1A1 couples transcription to translation during heat shock response. Elife 16:3e03164
VÃgh L, Literáti PN, Horváth I et al (1997) Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med 3:1150–1154
Wang Z, Lindquist S (1998) Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response. Development 125:4841–4850
Wang Z, Zang C, Cui K et al (2009) Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138:1019–1031
Westerheide SD, Bosman JD, Mbadugha BN et al (2004) Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem 279:56053–56060
Westerheide SD, Anckar J, Stevens SM Jr et al (2009) Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323:1063–1066
Winegarden NA, Wong KS, Sopta M et al (1996) Sodium salicylate decreases intracellular ATP, induces both heat shock factor binding and chromosomal puffing, but does not induce hsp 70 gene transcription in Drosophila. J Biol Chem 271:26971–26980
Wolff S, Weissman JS, Dillin A (2014) Differential scales of protein quality control. Cell 157:52–64
Wu C (1995) Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol 11:441–469
Xavier IJ, Mercier PA, McLoughlin CM et al (2000) Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1. J Biol Chem 275:29147–29152
Xia W, Voellmy R (1997) Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers. J Biol Chem 272:4094–4102
Xu D, Zalmas LP, La Thangue NB (2008) A transcription cofactor required for the heat-shock response. EMBO Rep 9:662–669
Zhong M, Orosz A, Wu C (1998) Direct sensing of heat and oxidation by Drosophila heat shock transcription factor. Mol Cell 2:101–108
Zhong M, Kim SJ, Wu C (1999) Sensitivity of Drosophila heat shock transcription factor to low pH. J Biol Chem 274:3135–3140
Zimarino V, Wilson S, Wu C (1990) Antibody-mediated activation of Drosophila heat shock factor in vitro. Science 249:546–549
Zimmerman JL, Petri W, Meselson M (1983) Accumulation of a specific subset of D. melanogaster heat shock mRNAs in normal development without heat shock. Cell 32:1161–1170
Zou J, Guo Y, Guettouche T et al (1998a) Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94:471–480
Zou J, Salminen WF, Roberts SM et al (1998b) Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response. Cell Stress Chaperones 3:130–141
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Takaki, E., Nakai, A. (2016). Regulation of HSF Activation and Repression. In: Nakai, A. (eds) Heat Shock Factor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55852-1_3
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