Skip to main content
SpringerLink
Log in
Book cover

Heat Shock Factor pp 243–259Cite as

HSF and Heart Diseases

  • Chapter
  • First Online:

  • 988 Accesses

Abstract

In the heart, HSF1 has a wide range of expression in many kinds of cells, including cardiac myocytes, fibroblasts, and endothelial cells, which governs the activation of heat shock proteins and plays a protective role against different pathological stimuli. HSF1 is activated by phosphorylation and transferred into the nucleus. HSPs also regulate HSF1 activity. HSF1 activity is required to maintain redox state and attenuate oxidative damage in the heart under normal physiological conditions. HSF1 protects against ischemia/reperfusion injury and myocardial infarction by inhibiting oxidative stress and cardiomyocyte apoptosis. HSF1 ameliorated death of cardiomyocytes and cardiac fibrosis and thereby prevented cardiac dysfunction as well as hypertrophy induced by chronic pressure overload. HSF1 promotes cardiac angiogenesis during chronic pressure overload, leading to the maintenance of cardiac adaptation. In atherosclerosis, however, HSF1 is activated and highly expressed in atherosclerotic lesions and that proinflammatory cytokine stimulation and disturbed mechanical stress to the vessel are primarily responsible for HSF1 activation in smooth muscle cells. In the failing hearts, HSF1 is increased, but nuclear translocation of the HSF1 is markedly reduced in the viable myocardium upon the pathological stresses. Thus, cardiac protective HSP induction is impaired in the failing heart.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Al-Shudiefat AR, Sharma A, Bagchi A, Dhingra S, Singal P (2013) Oleic acid mitigates TNF-α-induced oxidative stress in rat cardiomyocytes. Mol Cell Biochem 372(1–2):75–82

    Article  CAS  PubMed  Google Scholar 

  • Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z et al (2008) High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 117(25):3216–3226

    Article  CAS  PubMed  Google Scholar 

  • Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T et al (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2(8):469–475

    Article  CAS  PubMed  Google Scholar 

  • Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS (1992) Induction of stress proteins in cultured myogenic cells – molecular signals for the activation of heat-shock transcription factor during ischemia. J Clin Invest 89(5):1685–1689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berberian PA, Myers W, Tytell M, Challa V, Bond MG (1990) Immunohistochemical localization of heat-shock protein-70 in normal-appearing and atherosclerotic specimens of human arteries. Am J Pathol 136(1):71–80

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C et al (2000) Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2(9):645–652

    Article  CAS  PubMed  Google Scholar 

  • Buchman TG, Abello PA, Smith EH, Bulkley GB (1993) Induction of heat-shock response leads to apoptosis in endothelial-cells previously exposed to endotoxin. Am J Physiol 265(1):H165–H170

    CAS  PubMed  Google Scholar 

  • Chen Y, Currie RW (2006) Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-κB and AP-1 in vascular smooth muscle cells. Cardiovasc Res 69(1):66–75

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Arrigo A-P, Currie RW (2004) Heat shock treatment suppresses angiotensin II-induced activation of NF-κB pathway and heart inflammation: a role for IKK depletion by heat shock? Am J Physiol Heart Circ Physiol 287(3):H1104–H1114

    Article  CAS  PubMed  Google Scholar 

  • Chi NC, Karliner JS (2004) Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors. Cardiovasc Res 61(3):437–447

    Article  CAS  PubMed  Google Scholar 

  • Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK (1996) Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem 271(48):30847–30857

    Article  CAS  PubMed  Google Scholar 

  • Coaxum SD, Griffin TM, Martin JL, Mestril R (2007) Influence of PKC-alpha overexpression on HSP70 and cardioprotection. Am J Physiol Heart Circ Physiol 292(5):H2220–H2226

    Article  CAS  PubMed  Google Scholar 

  • Cooper ZA, Singh IS, Hasday JD (2010) Febrile range temperature represses TNF-alpha gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-alpha promoter. Cell Stress Chaperones 15(5):665–673

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Costa VM, Silva R, Ferreira R, Amado F, Carvalho F, de Lourdes BM et al (2009) Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. Toxicology 257(1–2):70–79

    Article  CAS  PubMed  Google Scholar 

  • Currie RW, Karmazyn M (1990) Improved post-ischemic ventricular recovery in the absence of changes in energy metabolism in working rat hearts following heat-shock. J Mol Cell Cardiol 22(6):631–636

    Article  CAS  PubMed  Google Scholar 

  • Dai RJ, Frejtag W, He B, Zhang Y, Mivechi NF (2000) c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. J Biol Chem 275(24):18210–18218

    Article  CAS  PubMed  Google Scholar 

  • Eriksson M, Jokinen E, Sistonen L, Leppa S (2000) Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol 44(5):471–477

    CAS  PubMed  Google Scholar 

  • Fiorenza MT, Farkas T, Dissing M, Kolding D, Zimarino V (1995) Complex expression of murine heat-shock transcription factors. Nucleic Acids Res 23(3):467–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fryer RM, Wang Y, Hsu AK, Gross GJ (2001) Essential activation of PKC-delta in opioid-initiated cardioprotection. Am J Physiol Heart Circ Physiol 280(3):H1346–H1353

    CAS  PubMed  Google Scholar 

  • Gardoni F, Mauceri D, Marcello E, Sala C, Di Luca M, Jeromin A (2007) SAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: REGULATION BY CaMKII. J Biol Chem 282(39):28691–28699

    Article  CAS  PubMed  Google Scholar 

  • Guettouche T, Boellmann F, Lane WS, Voellmy R (2005) Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem 6:4

    Article  PubMed  PubMed Central  Google Scholar 

  • Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt WB, Toft DO et al (2001) Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem 276(49):45791–45799

    Article  CAS  PubMed  Google Scholar 

  • Haider AW, Larson MG, Benjamin EJ, Levy D (1998) Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol 32(5):1454–1459

    Article  CAS  PubMed  Google Scholar 

  • Hansson GK, Libby P, Schonbeck U, Yan ZQ (2002) Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91(4):281–291

    Article  CAS  PubMed  Google Scholar 

  • Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A et al (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20(14):3800–3810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holmberg CI, Tran SEF, Eriksson JE, Sistonen L (2002) Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends Biochem Sci 27(12):619–627

    Article  CAS  PubMed  Google Scholar 

  • Hutter MM, Sievers RE, Barbosa V, Wolfe CL (1994) Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation 89(1):355–360

    Article  CAS  PubMed  Google Scholar 

  • Inouye S, Izu H, Takaki E, Suzuki H, Shirai M, Yokota Y et al (2004) Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem 279(37):38701–38709

    Article  CAS  PubMed  Google Scholar 

  • Jolly C, Usson Y, Morimoto RI (1999) Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci USA 96(12):6769–6774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kanwar RK, Kanwar JR, Wang DM, Ormrod DJ, Krissansen GW (2001) Temporal expression of heat shock proteins 60 and 70 at lesion-prone sites during atherogenesis in ApoE-deficient mice. Arterioscler Thromb Vasc 21(12):1991–1997

    Article  CAS  Google Scholar 

  • Katz AM (1990) Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N Engl J Med 322(2):100–110

    Article  CAS  PubMed  Google Scholar 

  • Kim E, Sheng M (1996) Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. Neuropharmacology 35(7):993–1000

    Article  CAS  PubMed  Google Scholar 

  • Kleindienst R, Xu QB, Willeit J, Waldenberger FR, Weimann S, Wick G (1993) Immunology of atherosclerosis – demonstration of heat-shock protein-60 expression and T-lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions. Am J Pathol 142(6):1927–1937

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kline MP, Morimoto RI (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17(4):2107–2115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Knowlton AA (2006) NFκB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res 69(1):7–8

    Article  CAS  PubMed  Google Scholar 

  • Knowlton AA, Sun L (2001) Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol 280(1):H455–H464

    CAS  PubMed  Google Scholar 

  • Kobba S, Kim SC, Chen L, Kim E, Tran AL, Knuefermann P et al (2011) The heat shock paradox and cardiac myocytes: role of heat shock factor. Shock 35(5):478–484

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lautier D, Lagueux J, Thibodeau J, Menard L, Poirier GG (1993) Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 122(2):171–193

    Article  CAS  PubMed  Google Scholar 

  • Lepore DA, Knight KR, Anderson RL, Morrison WA (2001) Role of priming stresses and Hsp70 in protection from ischemia-reperfusion injury in cardiac and skeletal muscle. Cell Stress Chaperones 6(2):93–96

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP (1990) Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322(22):1561–1566

    Article  CAS  PubMed  Google Scholar 

  • Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI et al (2007) HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 293(4):H2238–H2247

    Article  CAS  PubMed  Google Scholar 

  • Liu GS, Cohen MV, Mochly-Rosen D, Downey JM (1999) Protein kinase C- ξ is responsible for the protection of preconditioning in rabbit cardiomyocytes. J Mol Cell Cardiol 31(10):1937–1948

    Article  CAS  PubMed  Google Scholar 

  • Ma H, Gong H, Chen Z, Liang Y, Yuan J, Zhang G et al (2012) Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J Mol Cell Cardiol 52(6):1282–1290

    Article  CAS  PubMed  Google Scholar 

  • Marber MS, Mestril R, Chi SH, Sayen MR, Yellon DM, Dillmann WH (1995) Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 95(4):1446–1456

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marunouchi T, Araki M, Murata M, Takagi N, Tanonaka K (2013a) Possible involvement of HSP90-HSF1 multichaperone complex in impairment of HSP72 induction in the failing heart following myocardial infarction in rats. J Pharmacol Sci 123(4):336–346

    Article  CAS  PubMed  Google Scholar 

  • Marunouchi T, Murata M, Takagi N, Tanonaka K (2013b) Possible involvement of phosphorylated heat-shock factor-1 in changes in heat shock protein 72 induction in the failing rat heart following myocardial infarction. Biol Pharm Bull 36(8):1332–1340

    Article  CAS  PubMed  Google Scholar 

  • Mehlen P, Kretz-Remy C, Préville X, Arrigo AP (1996) Human hsp27, drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J 15(11):2695–2706

    CAS  PubMed  PubMed Central  Google Scholar 

  • Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu YH et al (2003) Activation of heat shock transcription factor 1 in atherosclerosis. Am J Pathol 162(5):1669–1676

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (1997) HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17(1):469–481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakai A, Suzuki M, Tanabe M (2000) Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J 19(7):1545–1554

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Neef DW, Jaeger AM, Thiele DJ (2011) Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov 10(12):930–944

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Niemann-Jonsson A, Dimayuga P, Jovinge S, Calara F, Ares MPS, Fredrikson GN et al (2000) Accumulation of LDL in rat arteries is associated with activation of tumor necrosis factor-alpha expression. Arterioscler Thromb Vasc 20(10):2205–2211

    Article  CAS  Google Scholar 

  • Nishizawa J, Nakai A, Matsuda K, Komeda M, Ban T, Nagata K (1999) Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart. Circulation 99(7):934–941

    Article  CAS  PubMed  Google Scholar 

  • Nishizawa J, Nakai A, Komeda M, Ban T, Nagata K (2002) Increased preload directly induces the activation of heat shock transcription factor 1 in the left ventricular overloaded heart. Cardiovasc Res 55(2):341–348

    Article  CAS  PubMed  Google Scholar 

  • Okada K-i, Minamino T, Kitakaze M (2005) The role of endoplasmic reticulum stress in hypertrophic and failing hearts subtitle_in_Japanese. Folia Pharmacol Jpn 126(6):385–389

    Article  CAS  Google Scholar 

  • Okubo S, Wildner O, Shah MR, Chelliah JC, Hess ML, Kukreja RC (2001) Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart. Circulation 103(6):877–881

    Article  CAS  PubMed  Google Scholar 

  • Paroo Z, Meredith MJ, Locke M, Haist JV, Karmazyn M, Noble EG (2002) Redox signaling of cardiac HSF1 DNA binding. Am J Physiol Cell Physiol 283(2):C404–C411

    Article  CAS  PubMed  Google Scholar 

  • Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao C-M et al (2010) Cardioprotection by CaMKII-δB is mediated by phosphorylation of HSF1 and subsequent expression of inducible HSP70. Circ Res 106(1):102

    Article  CAS  PubMed  Google Scholar 

  • Pluim BM, Zwinderman AH, van der Laarse A, van der Wall EE (2000) The athlete’s heart. A meta-analysis of cardiac structure and function. Circulation 101(3):336–344

    Article  CAS  PubMed  Google Scholar 

  • Rauvala H, Rouhiainen A (2010) Physiological and pathophysiological outcomes of the interactions of HMGB1 with cell surface receptors. Biochim Biophys Acta 1799(1–2):164–170

    Article  CAS  PubMed  Google Scholar 

  • Rocnik E, Chow LH, Pickering JG (2000) Heat shock protein 47 is expressed in fibrous regions of human atheroma and is regulated by growth factors and oxidized low-density lipoprotein. Circulation 101(11):1229–1233

    Article  CAS  PubMed  Google Scholar 

  • Ruwhof C, van der Laarse A (2000) Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 47(1):23–37

    Article  CAS  PubMed  Google Scholar 

  • Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M et al (2006) Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res 99(12):1411–1418

    Article  CAS  PubMed  Google Scholar 

  • Singh IS, He J-R, Calderwood S, Hasday JD (2002) A high affinity HSF-1 binding site in the 5′-untranslated region of the murine tumor necrosis factor-α gene is a transcriptional repressor. J Biol Chem 277(7):4981–4988

    Article  CAS  PubMed  Google Scholar 

  • Snoeckx LHEH, Cornelussen RN, Van Nieuwenhoven FA, Reneman RS, Van Der Vusse GJ (2001) Heat shock proteins and cardiovascular pathophysiology. Physiol Rev 81(4):1461–1497

    CAS  PubMed  Google Scholar 

  • Sreedhar AS, Csermely P (2004) Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy – a comprehensive review. Pharmacol Ther 101(3):227–257

    Article  CAS  PubMed  Google Scholar 

  • Suzuki K, Sawa Y, Kaneda Y, Ichikawa H, Shirakura R, Matsuda H (1997) In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat. J Clin Invest 99(7):1645–1650

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tani M, Suganuma Y, Hasegawa H, Shinmura K, Hayashi Y, Guo XD et al (1997) Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts. Circulation 95(11):2559–2566

    Article  CAS  PubMed  Google Scholar 

  • Ting YK, Morikawa K, Kurata Y, Li P, Bahrudin U, Mizuta E et al (2011) Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v)1.5 channels in HL-1 cells. Br J Pharmacol 162(8):1832–1842

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Toko HU, Minamino T, Komuro I (2008) Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy. Trends Cardiovasc Med 18(3):88–93

    Article  CAS  PubMed  Google Scholar 

  • Verma S, Fedak PW, Weisel RD, Butany J, Rao V, Maitland A et al (2002) Fundamentals of reperfusion injury for the clinical cardiologist. Circulation 105(20):2332–2336

    Article  PubMed  Google Scholar 

  • Wang Y, Chen L, Hagiwara N, Knowlton AA (2010) Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol 48(2):360–366

    Article  CAS  PubMed  Google Scholar 

  • Westerheide SD, Morimoto RI (2005) Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 280(39):33097–33100

    Article  CAS  PubMed  Google Scholar 

  • Williams RS, Benjamin IJ (2000) Protective responses in the ischemic myocardium. J Clin Invest 106(7):813–818

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Witztum JL, Steinberg D (2001) The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc Med 11(3–4):93–102

    Article  CAS  PubMed  Google Scholar 

  • Wizorek JJ, Coopersmith CM, Laramie JM, Tong A, Stromberg PE, Hotchkiss RS et al (2004) Sequence makes a difference: paradoxical effects of stress in vivo. Shock 22(3):229–233

    Article  PubMed  Google Scholar 

  • Wu L, Hu C, Huang M, Jiang M, Lu L, Tang J (2013) Heat shock transcription factor 1 attenuates TNFα-induced cardiomyocyte death through suppression of NFκB pathway. Gene 527(1):89–94

    Article  CAS  PubMed  Google Scholar 

  • Xavier IJ, Mercier PA, McLoughlin CM, Ali A, Woodgett JR, Ovsenek N (2000) Glycogen synthase kinase 3β negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1. J Biol Chem 275(37):29147–29152

    Article  CAS  PubMed  Google Scholar 

  • Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA et al (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18(21):5943–5952

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK (2002) Heat shock factor 1 represses transcription of theIL-1β gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem 277(14):11802–11810

    Article  CAS  PubMed  Google Scholar 

  • Xie Y, Zhong R, Chen CM, Calderwood SK (2003) Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes. J Biol Chem 278(7):4687–4698

    Article  CAS  PubMed  Google Scholar 

  • Xu QB (2002) Role of heat shock proteins in atherosclerosis. Arterioscler Thromb Vasc 22(10):1547–1559

    Article  CAS  Google Scholar 

  • Xu Q, Schett G, Li C, Hu Y, Wick G (2000) Mechanical stress–induced heat shock protein 70 expression in vascular smooth muscle cells is regulated by Rac and Ras small G proteins but not mitogen-activated protein kinases. Circ Res 86(11):1122–1128

    Article  CAS  PubMed  Google Scholar 

  • Yan LJ, Christians ES, Liu L, Xiao X, Sohal RS, Benjamin IJ (2002) Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J 21(19):5164–5172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yellon DM, Pasini E, Cargnoni A, Marber MS, Latchman DS, Ferrari R (1992) The protective role of heat stress in the ischaemic and reperfused rabbit myocardium. J Mol Cell Cardiol 24(8):895–907

    Article  CAS  PubMed  Google Scholar 

  • Yu Y, Liu M, Zhang L, Cao Q, Zhang P, Jiang H et al (2012) Heat shock transcription factor 1 inhibits H2O2-induced cardiomyocyte death through suppression of high-mobility group box 1. Mol Cell Biochem 364(1–2):263–269

    Article  CAS  PubMed  Google Scholar 

  • Zhang L, Jiang H, Gao XQ, Zou YZ, Liu M, Liang YY et al (2011) Heat shock transcription factor-1 inhibits H2O2-induced apoptosis via down-regulation of reactive oxygen species in cardiac myocytes. Mol Cell Biochem 347(1–2):21–28

    Article  CAS  PubMed  Google Scholar 

  • Zingarelli B, Hake PW, O’Connor M, Denenberg A, Wong HR, Kong S et al (2004) Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. Am J Physiol Heart Circ Physiol 286(4):H1408–H1415

    Article  CAS  PubMed  Google Scholar 

  • Zingarelli B, Hake PW, Mangeshkar P, O’Connor M, Burroughs TJ, Piraino G et al (2007) Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin j(2) and ciglitazone, in reperfusion injury: role of nuclear factor-kappa B, heat shock factor 1, and Akt. Shock 28(5):554–563

    CAS  PubMed  Google Scholar 

  • Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H et al (2003) Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 108(24):3024–3030

    Article  CAS  PubMed  Google Scholar 

  • Zou Y, Li J, Ma H, Jiang H, Yuan J, Gong H et al (2011) Heat shock transcription factor 1 protects heart after pressure overload through promoting myocardial angiogenesis in male mice. J Mol Cell Cardiol 51(5):821–829

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Jie Yuan & Yunzeng Zou

Authors
  1. Jie Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yunzeng Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yunzeng Zou .

Editor information

Editors and Affiliations

  1. Department of Biochemistry & Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan

    Akira Nakai

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Japan

About this chapter

Cite this chapter

Yuan, J., Zou, Y. (2016). HSF and Heart Diseases. In: Nakai, A. (eds) Heat Shock Factor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55852-1_12

Download citation

Publish with us

Policies and ethics

Search

Navigation