Abstract
Blood cell/protein damage and blood coagulation should be avoided in medical devices in design and in clinical use. Typical issues are hemolysis, thrombosis, and von Willebrand syndrome. Their mechanism of generation and the corresponding evaluation methods are also described here.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hashimoto, S.: Erythrocyte destruction under periodically fluctuating shear rate: comparative study with constant shear rate. J. Artif. Organs 13(5), 458–463 (1989). Blackwell
Giersiepen, M., Wurzinger, L.J., Opitz, R., Reul, H.: Estimation of shear stress-related blood damaga in heart valve prostheses-in vitro comparison of 25 aortic valves. Int. J. Artif. Organs 13(5), 300–306 (1990)
Nishida, M., Yamane, T., Masuzawa, T., Tsukiya, T., Taenaka, Y., Tsukamoto, Y., Ito, K., Konishi, Y.: Flow visualization study to obtain suitable design criteria of a centrifugal blood pump. J. Congest. Heart Fail. Circulat. Support 1(4), 311–315 (2001)
Nevaril, C.G., Hellums, J.D., Alfrey Jr., C.P., Lynch, E.C.: Physical effects in red blood cell trauma. A.I.Ch.E. J. 15, 707 (1969)
Schima, H., Wieselthaler, G., Schwendenwein, I., Losert, U., Wolner, E.: A review and assessment of investigative methods for mechanically induced blood trauma: special aspects in rotary blood pumps. Heart Replace Artif. Heart 6, 361–367 (1998)
ISO 10993–4 Biological evaluation of medical devices — Part 4: Selection of tests for interactions with blood
Toyoda, M., Nishida, M., Maruyama, O., Yamane, T., Tsutsui, T., Sankai, Y.: Geometric optimization for non-thrombogenicity of a centrifugal blood pump through flow visualization. JSME Int. J. C 45(4), 1013–1019 (2002)
Yamane, T., Maruyama, O., Nishida, M., Toyoda, M., Tsutsui, T., Jikuya, T., Shigeta, O., Sankai, Y.: The most profitable use of flow visualization in the elimination of thrombus from a monopivot magnetic suspension blood pump. J. Artif Organs 28(4), 390–397 (2004). Blackwell
Crow, S., Chen, D., Milano, C., Thomas, W., Joyce, L., Piacentino III, V., Sharma, R., Wu, J., Arepally, G., Bowles, D., Rogers, J., Villamizar-Ortiz, N.: Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann. Thorac. Surg. 90, 1263–1269 (2010)
ASTM F-1830-97, Standard practice for selection of blood for in-vitro evaluation of blood pumps (1997)
ASTM F1841-97, Standard practice for Assessment of hemolysis in continuous flow blood pumps (1997)
ISO/CD 18242, Cardiovascular implants and extracorporeal systems — Centrifugal blood pumps
ISO 10993–4, Biological evaluation of medical devices — Part 4: Selection of tests for interactions with blood, 2013-01-10
Maruyama, O., Tomari, Y., Sugiyama, D., Nishida, M., Tsustui, T., Yamane, T.: Simple in vitro testing method for antithrombogenic evaluation of centrifugal blood pumps. ASAIO J. 55(4), 314–322 (2009)
ISO 14708–5, Implants for surgery — Active implantable medical devices — Part 5: Circulatory support devices, 2010-02-01
Thrall, M.A., Weiser, G., Allison, R.W., Campbell, T.W.: Veterinary Hematology and Clinical Chemistry, 2nd edn. Wiley-Blackwell, Somerset (2012)
Tanaka, H., Tsukiya, T., Tatsumi, E., Mizuno, T., Hidaka, T., Okubo, T., Osada, T., Miyamoto, S., Taenaka, Y.: Initial in vivo evaluation of the newly developed axial flow turbo pump with hydrodynamic bearings. J. Artif. Organs 14(1), 31–38 (2011). Springer
Yamane, T., Kosaka, R., Nishida, M., Maruyama, O., Yamamoto, Y., Kuwana, K., Kawamura, H., Shiraishi, Y., Yambe, T., Sankai, Y., Tsutsui, T.: Enhancement of hemocompatibility of the MERA monopivot centrifugal pump: toward medium-term use. J. Artif. Organs 37(2), 217–225 (2013). Wiley-Blackwell
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Japan
About this chapter
Cite this chapter
Yamane, T. (2016). Enhancement of Hemocompatibility. In: Mechanism of Artificial Heart. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55831-6_8
Download citation
DOI: https://doi.org/10.1007/978-4-431-55831-6_8
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-55829-3
Online ISBN: 978-4-431-55831-6
eBook Packages: EngineeringEngineering (R0)