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Murine Models of Vein Grafting

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Abstract

Vein graft research has increasingly turned to murine models, to exploit the potential of transgenic and knockout mouse lines to study genetically based questions. Several models of murine interpositional vein grafting into arteries have been published, as well as models of vein patch grafting. Models vary on the vein graft source (inferior vena cava, external jugular vein or its distal branches), recipient artery (aorta, carotid, or femoral), and method of engraftment (end-to-end or end-to-side continuous or interrupted suturing or ring-coupling techniques). Outcomes vary considerably, depending on the model employed; neointimal wall thickening is induced that is often comparable to larger vein graft models on an absolute basis, despite the much smaller vessel diameters of mouse vein grafts. Substantial vein graft stenosis is apparently only found with the smaller of these vein graft models. Selecting the appropriate model requires careful consideration of the specific research question to be addressed as well as laboratory expertise with microsurgical techniques.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Rodent Advanced Surgical Models Core Lab, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, 27599, USA

    Brian C. Cooley

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  1. Brian C. Cooley
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Correspondence to Brian C. Cooley .

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  1. Tokushima University, Tokushima, Japan

    Masataka Sata

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Cooley, B.C. (2016). Murine Models of Vein Grafting. In: Sata, M. (eds) Mouse Models of Vascular Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55813-2_7

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  • DOI: https://doi.org/10.1007/978-4-431-55813-2_7

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55811-8

  • Online ISBN: 978-4-431-55813-2

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