Skip to main content

Infectious Diseases (Non-hepatitis Virus Infection) and the Liver

  • Chapter
  • First Online:
The Liver in Systemic Diseases

Abstract

Many microorganisms are related to liver injury. Several representative viral diseases are shown and discussed in this chapter. Epstein Barr virus, human cytomegalovirus, herpes simplex virus, herpes zoster virus and human herpesvirus 6 belong to the genus herpesviridae. Most of them may cause severe hepatitis in immunocompromised hosts with symptoms. Liver injury is milder in immunocompetent patients. Diagnosis of hepatitis caused by these viruses are based on nucleic acid and serological tests. However, the diagnosis remains unestablished in most viruses. The treatment and prevention are just symptomatic in most occasion. Parvovirus B19 infection causes liver injury with typical eruption and red cell aplasia. Dengue, which belongs to the genus flaviviridae and is transmitted by mosquito are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cohen JI. Epstein-Barr virus infection. N Engl J Med. 2000;343:481–92.

    Article  CAS  PubMed  Google Scholar 

  2. Dienes HP, Drebber U. Pathology of immune-mediated liver injury. Dig Dis. 2010; 28:57–62. Drebber U et al. The role of Epstein-Barr virus in acute and chronic hepatitis. J Hepatol. 2006; 44: 879–885.

    Google Scholar 

  3. Takeuchi K, Tanaka-Taya K, Kazuyama Y, Ito YM, Hashimoto S, Fukayama M, Mori S. Prevalence of Epstein-Barr virus in Japan: trends and future prediction. Pathol Int. 2006;56:112–6.

    Article  PubMed  Google Scholar 

  4. Papatheodoridis GV, Delladetsima JK, Kavallierou L, Kapranos N, Tassopoulos NC. Fulminant hepatitis due to Epstein-Barr virus infection. J Hepatol. 1995;23:348–50.

    Article  CAS  PubMed  Google Scholar 

  5. Harrington P, Gutiérrez J, Ramírez-Ronda C, Quinones-Soto R, Bermúdez R, Chaffey J. Granulomatous hepatitis. Rev Infect Dis. 1982;4:638–55.

    Article  CAS  PubMed  Google Scholar 

  6. Petrova M, Muhtarova M, Nikolova M, Magaev S, Taskov H, Nikolovska D, Krastev Z. Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients. World J Gastroenterol. 2006;12:5711–6.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Smets F, Bodeus M, Goubau P, Reding R, Otte JB, Buts JP, Sokal EM. Characteristics of Epstein-Barr virus primary infection in pediatric liver transplant recipients. J Hepatol. 2000;32:100–4.

    Article  CAS  PubMed  Google Scholar 

  8. Kofteridis DP, Koulentaki M, Valachis A, et al. Epstein Barr virus hepatitis. Eur J Intern Med. 2011;22:73–6.

    Article  PubMed  Google Scholar 

  9. Sinzger C, Digel M, Jahn G. Cytomegalovirus cell tropism. Curr Top Microbiol Immunol. 2008;325:63–83.

    CAS  PubMed  Google Scholar 

  10. Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006;177(10):7094–102.

    Article  CAS  PubMed  Google Scholar 

  11. von Muller L, Klemm A, Durmus N, Weiss M, Suger-Wiedeck H, Schneider M, Hampl W, Mertens T. Cellular immunity and active human cytomegalovirus infection in patients with septic shock. J Infect Dis. 2007;196:1288–95.

    Article  Google Scholar 

  12. Paya CV, Hermans PE, Wiesner RH, Ludwig J, Smith TF, Rakela J, Krom RA. Cytomegalovirus hepatitis in liver transplantation: prospective analysis of 93 consecutive orthotopic liver transplantations. J Infect Dis. 1989;160:752–8.

    Article  CAS  PubMed  Google Scholar 

  13. Balfour HJ. Antiviral drugs. N Engl J Med. 1999;340:1255–68.

    Article  CAS  PubMed  Google Scholar 

  14. Montalbano M, Slapak-Green GI, Neff GW. Fulminant hepatic failure from herpes simplex virus: post liver transplantation acyclovir therapy and literature review. Transplant Proc. 2005;37:4393–6.

    Article  CAS  PubMed  Google Scholar 

  15. Kang AH, Graves CR. Herpes simplex hepatitis in pregnancy: a case report and review of the literature. Obst Gynecol Survey. 1999;54:463–8.

    Article  CAS  Google Scholar 

  16. Benador N, Mannhardt W, Schranz D, Braegger C, Fan- coni S, Hassam S, et al. Three cases of neonatal herpes simplex virus infection presenting as fulminant hepatitis. Eur J Pediatr. 1990;149:555–9.

    Article  CAS  PubMed  Google Scholar 

  17. Whitley RJ. Neonatal herpes simplex virus infections. Presentation and management. J Reprod Med. 1986;31(5 Suppl):426–32.

    CAS  PubMed  Google Scholar 

  18. Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Frenkel LM, Gruber WC, Rathore M, Bradley JS, Diaz PS, Kumar M, Arvin AM, Gutierrez K, Shelton M, Weiner LB, Sleasman JW, de Sierra TM, Soong SJ, Kiell J, Lakeman FD, Whitley RJ, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics. 2001;108:223–9.

    Article  CAS  PubMed  Google Scholar 

  19. Klein NA, Mabie WC, Shaver DC, Latham PS, Adamec TA, Pinstein ML, Riely CA. Herpes simplex virus hepatitis in pregnancy. Two patients successfully treated with acyclovir. Gastroenterology. 1991;100:239–44.

    Article  CAS  PubMed  Google Scholar 

  20. Yuasa M, Ishiwata K, Sugio T, Kaji D, Ota H, Tsuji M, Yamamoto H, Yamamoto G, Asano-Mori Y, Uchida N, Izutsu K, Taniguchi S. Herpes simplex virus type 2 fulminant hepatitis after umbilical cord blood transplantation for acute myeloid leukemia. Rinsho Ketsueki. 2014;55:682–6 [Article in Japanese].

    PubMed  Google Scholar 

  21. Minuk G, Nicolle L. Genital herpes and hepatitis in healthy young adults. J Med Virol. 1986;19:269–75.

    Article  CAS  PubMed  Google Scholar 

  22. Velasco M, Llamas E, Guijarro-Rojas M, Ruiz-Yague M. Fulminant herpes hepatitis in a healthy adult: a treatable disorder? J Clin Gastroenterol. 1999;28:386–9.

    Article  CAS  PubMed  Google Scholar 

  23. Ku CC, et al. Varicella-zoster virus transfer to skin by T cells and modulation of viral replication by epidermal cell interferon-α. J Exp Med. 2004;200:917–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Gilden DH, et al. Varicella-zoster virus DNA in human sensory ganglia. Nature. 1983;306:478–48.

    Article  CAS  PubMed  Google Scholar 

  25. Morishita K, Kodo H, Asano S, Fujii H, Miwa S. Fulminant varicella hepatitis following bone marrow transplantation. JAMA. 1985;253:511.

    Article  CAS  PubMed  Google Scholar 

  26. Plisek S, Pliskova L, Bostik V, Prasil P, Laco J, Chlibek R, Vyroubal P, Kosina P, Bostik P. Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild­type clade 4 varicella­zoster virus strain. J Clin Virol. 2011;50:72–5.

    Article  PubMed  Google Scholar 

  27. Okamoto A, Abe A, Okamoto M, Kobayashi T, Terazawa T, Inaguma Y, Tokuda M, Yanada M, Morishima S, Kanie T, Yamamoto Y, Tsuzuki M, Akatsuka Y, Mizuta S, Yoshikawa T, Emi N. Severe hepatitis associated with varicella zoster virus infection in a patient with diffuse large B cell lymphoma treated with rituximab­CHOP chemotherapy. Int J Hematol. 2012;96:516–20.

    Article  PubMed  Google Scholar 

  28. Alonso EM, Fox AS, Franklin WA, Whitington PF. Post- necrotic cirrhosis following varicella hepatitis in a liver transplant patient. Transplantation. 1990;49:650–3.

    Article  CAS  PubMed  Google Scholar 

  29. Yamada N, Sanada Y, Okada N, Wakiya T, Ihara Y, Urahashi T, Mizuta K. Successful rescue of disseminated varicella infection with multiple organ failure in a pediatric living donor liver transplant recipient: a case report and literature review. Virol J. 2015;12:91.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Plotkin SA. Clinical and pathogenetic aspects of varicella-zoster. Postgrad Med J. 1985;61 Suppl 4:7–14.

    PubMed  Google Scholar 

  31. Beby­Defaux A, Brabant S, Chatellier D, Bourgoin A, Robert R, Ruckes T, Agius G. Disseminated varicella with multiorgan failure in an immunocompetent adult. J Med Virol. 2009;81:747–9.

    Article  PubMed  Google Scholar 

  32. Petrun B, Williams V, Brice S. Disseminated varicella­zoster virus in an immunocompetent adult. Dermatol Online J. 2015; 21: pii: 13030/qt3cz2x99b.

    Google Scholar 

  33. Huang LM, Lee CY, Chen JY, Yang CS, Wang JD, Chang MH, Hsu CY, Kuo PF. Primary human herpesvirus 6 infections in children: a prospective serologic study. J Infect Dis. 1992;165:1163–4.

    Article  CAS  PubMed  Google Scholar 

  34. Aita K, Jin Y, Irie H, Takahashi I, Kobori K, Nakasato Y, Kodama H, Yanagawa Y, Yoshikawa T, Shiga J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion. Hum Pathol. 2001;32:887–9.

    Article  CAS  PubMed  Google Scholar 

  35. Ohashi M, Yoshikawa T, Asonuma K, Iwasaki T, Nishiyama Y, Asano Y, Kimoto Y, Yagi T, Urushihara N, Tanaka N, Baba K. Human herpesvirus 6 fulminant hepatic failure treated by living donor liver transplantation. Pediatr Int. 2004;46:730–2.

    Article  PubMed  Google Scholar 

  36. Härmä M, Höckerstedt K, Lautenschlager I. Human herpesvirus-6 and acute liver failure. Transplantation. 2003;76:536–9.

    Article  PubMed  Google Scholar 

  37. Buyse S, Roque-Afonso AM, Vaghefi P, Gigou M, Dussaix E, Duclos-Vallée JC, Samuel D, Guettier C. Acute hepatitis with periportal confluent necrosis associated with human herpesvirus 6 infection in liver transplant patients. Am J Clin Pathol. 2013;140:403–9.

    Article  PubMed  Google Scholar 

  38. Kuntzen T, Friedrichs N, Fischer HP, Eis-Hübinger AM, Sauerbruch T, Spengler U. Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction. Eur J Gastroenterol Hepatol. 2005;17:1131–4.

    Article  PubMed  Google Scholar 

  39. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, Pecorari M, Masetti M, Di Benedetto F, Gennari W, Portolani M, Gerunda GE, Lazzarotto T, Landini MP, Schulz TF, Torelli G, Guaraldi G. HHV-6A in syncytial giant-cell hepatitis. N Engl J Med. 2008;359:593–602.

    Article  CAS  PubMed  Google Scholar 

  40. Pischke S, Gösling J, Engelmann I, Schlue J, Wölk B, Jäckel E, Meyer­Heithuis C, Lehmann U, Strassburg CP, Barg­Hock H, Becker T, Manns MP, Schulz T, Wedemeyer H, Heim A. High intrahepatic HHV­6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis. J Hepatol. 2012;56:1063–9.

    Article  PubMed  Google Scholar 

  41. Arista S, DeGrazia S, DiMarco V, DiStefano R, Craxı A. Arvovirus B19 and “cryptogenic” chronic hepatitis. J Hepatol. 2003;38:375–6.

    Article  PubMed  Google Scholar 

  42. Bihari C, Rastogi A, Saxena P, Rangegowda D, Chowdhury A, Gupta N, Sarin SK. Parvovirus B19 associated hepatitis. Hepat Res Treat. 2013. http://dx.doi.org/10.1155/2013/472027

  43. Langnas AN, Markin RS, Cattral MS, Naides SJ. Parvovirus B19 as a possible causative agent of fulminant liver failure and associated aplastic anemia. Hepatology. 1995;22:1661–5.

    CAS  PubMed  Google Scholar 

  44. Sokal EM, Melchior M, Cornu C, et al. Cute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Lancet. 1998;352:1739–41.

    Article  CAS  PubMed  Google Scholar 

  45. Marianneau P, Steffan AM, Royer C, Drouet MT, Jaeck D, Kirn A, Deubel V. Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident. J Virol. 1999;73:5201–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Thongtan T, Panyim S, Smith DR. Apoptosis in dengue virus infected liver cell lines HepG2 and Hep3B. J Med Virol. 2004;72:436–44.

    Article  CAS  PubMed  Google Scholar 

  47. Miller JL, de Wet BJ, Martinez-Pomares L, Radcliffe CM, Dwek RA, Rudd PM, Gordon S. The mannose receptor mediates dengue virus infection of macrophages. PLoS Pathog. 2008;4, e17.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Parkash O, Almas A, Jafri SW, Hamid S, Akhtar J, Alishah H. Severity of acute hepatitis and its outcome in patients with dengue fever in a tertiary care hospital Karachi, Pakistan (South Asia). BMC Gastroenterol. 2010;10:43–50.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Trung DT, le Thao TT, Hien TT, et al. Liver involvement associated with dengue infection in adults in Vietnam. Am J Trop Med Hyg. 2010;83:774–80.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Samanta J, Sharma V. Dengue and its effects on liver. World J Clin Cases. 2015;3:125–31.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Thomas L, Verlaeten O, Cabié A, Kaidomar S, Moravie V, Martial J, Najioullah F, Plumelle Y, Fonteau C, Dussart P, Césaire R. Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic. Am J Trop Med Hyg. 2008;78:990–8.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiroshi Yotsuyanagi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Japan

About this chapter

Cite this chapter

Yotsuyanagi, H. (2016). Infectious Diseases (Non-hepatitis Virus Infection) and the Liver. In: Ohira, H. (eds) The Liver in Systemic Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55790-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-55790-6_16

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55789-0

  • Online ISBN: 978-4-431-55790-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics