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Clinical Applications of Magnetoencephalography pp 275–288Cite as

Schizophrenia

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Abstract

Despite the high prevalence of schizophrenia, which is a devastating mental disorder, the etiology and pathophysiology of this disease are still unclear. Magnetoencephalography (MEG) has a high spatial and temporal resolution and has been used to make important contributions to schizophrenia research. In this chapter, we review MEG studies of schizophrenia, with an emphasis on event-related responses and neural oscillations. Published MEG studies suggest that patients with schizophrenia have neurophysiological deficits from the early phase of sensory processing (i.e., M50, M100, mismatch negativity) in auditory perception. Moreover, schizophrenia patients may have altered neural oscillations, and abnormalities of auditory steady-state responses to 40 Hz click stimuli are repeatedly reported. Because this research can be conducted in living schizophrenia patients, these biological results are highly valuable for understanding the etiology and pathophysiology of the disorder. As advanced medical technology becomes increasingly globally available, the clinical application of MEG to schizophrenia treatment may be imminent.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Toshiaki Onitsuka & Shogo Hirano

  2. Neural Dynamics Laboratory, Research Service, Veterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Research 151C, 150 S. Huntington Ave, Boston, MA, 02130, USA

    Shogo Hirano

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  1. Toshiaki Onitsuka
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Correspondence to Toshiaki Onitsuka .

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Editors and Affiliations

  1. Department of Clinical Neurophysiology, Kyushu University, Higashi-ku, Fukuoka, Japan

    Shozo Tobimatsu

  2. Natl. Inst. for Physiological Scien, Dept. of Integrative Physiology, Okazaki, Aichi, Japan

    Ryusuke Kakigi

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Onitsuka, T., Hirano, S. (2016). Schizophrenia. In: Tobimatsu, S., Kakigi, R. (eds) Clinical Applications of Magnetoencephalography. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55729-6_14

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