Fracture Risk in Diabetes

  • Masahiro YamamotoEmail author
  • Toshitsugu Sugimoto


Meta-analyses have revealed that the relative risk of hip fractures in patients with type 1 and type 2 diabetes mellitus is higher than that in nondiabetic subjects. The risk of fracture in diabetic patients increases along with a decrease in bone mineral density (BMD) similarly to those in nondiabetic patients. However, the observed risk of fracture is higher than the expected one by BMD in both type 1 and type 2 diabetic patients, indicating that precise estimation of bone fragility by BMD values in patients with diabetes is difficult. Bone strength consists of BMD and bone quality; for this reason, poor bone quality is the most suitable and explicable cause for elevated fracture risk in this population. Bone quality indicators closely related to bone fragility are required to be identified to establish a diagnostic method for osteoporosis in diabetic patients.


Bone quality Low bone turnover Vertebral fracture pentosidine Advanced glycation end products (AGEs) 


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© Springer Japan 2016

Authors and Affiliations

  1. 1.Internal Medicine 1Shimane University Faculty of MedicineIzumoJapan

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