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Ghrelin and Gut Hormone

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Helicobacter pylori

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Abstract

One of the important gastric physiologies is the endocrine function. Among peptide hormones produced in the stomach, gastrin and somatostatin which are produced from G and D cell, respectively, are closely related with acid secretion, while ghrelin and leptin are known to be involved in gut motility as well as the regulation of appetite and body weight. Since Helicobacter pylori (H. pylori) is the major etiologic agent of chronic active gastritis, H. pylori infection can alter gastric hormone production. While the effect of H. pylori infection and its eradication on G and D cells and subsequent acid secretion has been relatively well investigated, its effect on ghrelin and leptin levels has been inconclusive. This discrepancy originates from different measurement methodology or existence of several types in one hormone. In addition, the different stage of H. pylori infection or site of the infection may cause a different result on ghrelin levels in the stomach and blood similar to the case of acid secretion. H. pylori infection seems to raise gastric leptin production, but its effect on circulating level is not much. Understanding the effect of H. pylori infection and eradication on gastric hormonal changes might provide a critical clinical implication for the management of gastrointestinal diseases as well as obesity or eating disorder.

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  1. Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea

    Yoon Jin Choi & Nayoung Kim

  2. Department of Internal Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, South Korea

    Nayoung Kim

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    Hidekazu Suzuki

  2. The Royal Perth Hospital, The University of Western Australia and, Western Australia, West Australia, Australia

    Robin Warren

  3. The Royal Perth Hospital, The University of Western Australia and, Western Australia, Australia

    Barry Marshall

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Choi, Y.J., Kim, N. (2016). Ghrelin and Gut Hormone. In: Suzuki, H., Warren, R., Marshall, B. (eds) Helicobacter pylori. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55705-0_6

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