Abstract
We investigated long-term outcomes (education, employment, marriage, fertility, multiple primary cancers, and psychosocial outcomes) and quality of life (QOL) in survivors of pediatric and adolescent osteosarcoma. In a limb-sparing group, the proportion of survivors who graduated from a university was significantly higher. There were few problems regarding employment. The marital rates were slightly lower in male survivors and in an amputation group. Recent chemotherapy affected male survivors’ fertility. Of 162 patients, 13 had multiple primary cancers. When reviewing psychosocial outcomes, the incidence of posttraumatic stress symptom was low, and posttraumatic growth was marked. The QOL was satisfactory, excluding “physical functioning.” The limb-sparing group was more adaptable to social life activities than the amputation group.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Nagarajan R, Clohisy DR, Neglia JP, et al. Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing’s sarcoma: the childhood cancer survivor study. Br J Cancer. 2004;91:1858–65.
Yonemoto T, Ishii T, Takeuchi Y, et al. Education and employment in long-term survivors of high-grade osteosaroma: a Japanese single center experience. Oncology. 2007;72:274–8.
Yonemoto T, Tatezaki S, Ishii T, et al. Marriage and fertility in long-term survivors of high grade osteosarcoma. Am J Clin Oncol. 2003;26:513–6.
Yonemoto T, Ishii T, Takeuchi Y, et al. Recently intensified chemotherapy for high-grade osteosarcoma may affect fertility in long-term male survivors. Anticancer Res. 2009;29:763–7.
Yonemoto T, Tatezaki S, Ishii T, et al. Multiple primary cancers in patients with osteosarcoma: the influence of anticancer drugs and genetic factors. Am J Clin Oncol. 2004;27:220–4.
Yonemoto T, Kamibeppu K, Ishii T, et al. Psychosocial outcomes in long-term survivors of high-grade osteosaroma: a Japanese single-center experience. Anticancer Res. 2009;29:4287–90.
Yonemoto T, Kamibeppu K, Ishii T, et al. Posttraumatic stress symptom (PTSS) and posttraumatic growth (PTG) in parents of childhood, adolescent and young adult patients with high-grade osteosarcoma. Int J Clin Oncol. 2012;17:272–5.
Yonemoto T, Ishii T, Takeuchi Y, et al. Evaluation of quality of life (QOL) in long-term survivors of high-grade osteosaroma: a Japanese single center experience. Anticancer Res. 2007;27:3621–4.
Nagarajan R, Neglia JP, Clohisy DR, et al. Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study. Cancer. 2003;97:2554–64.
Novakovic B, Fears TR, Horowitz ME, et al. Late effects of therapy in survivors of Ewing’s sarcoma family tumors. J Pediatr Hematol Oncol. 1997;19:220–5.
Hays DM, Landsverk J, Sallan SE, et al. Educational, occupational, and insurance status of childhood cancer survivors in their fourth and fifth decades of life. J Clin Oncol. 1992;10:1397–406.
Nicholson HS, Mulvihill JJ, Byrne J. Late effects of therapy in adult survivors of osteosarcoma and Ewing’s sarcoma. Med Pediatr Oncol. 1992;20:6–12.
Williams D, Crofton PM, Levitt G. Does ifosfamide affect gonadal function? Pediatr Blood Cancer. 2008;50:347–51.
Longhi A, Macchiagodena M, Vitali G, et al. Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. J Pediatr Hematol Oncol. 2003;25:292–6.
Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233–8.
Turaka K, Shields CL, Meadows AT, et al. Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma. Pediatr Blood Cancer. 2012;59:121–5.
Goldsby R, Burke C, Nagarajan R, et al. Second solid malignancies among children, adolescents, and young adults diagnosed with malignant bone tumors after 1976: follow-up of a Children’s Oncology Group cohort. Cancer. 2008;113:2597–604.
Smilkstein G, Ashworth C, Montano D. Validity and reliability of the family APGAR as a test of family function. J Fam Pract. 1982;15:303–11.
Furukawa TA, Harai H, Hirai T, et al. Social support questionnaire among psychiatric patients with various diagnoses and normal controls. Soc Psychiatry Psychiatr Epidemiol. 1999;34:216–22.
Horowitz M, Wilner N, Alvarez W. Impact of event scale: a measure of subjective stress. Psychosom Med. 1979;41:209–18.
Tedeschi RG, Calhoun LG. The posttraumatic growth inventory: measuring the positive legacy of trauma. J Trauma Stress. 1996;9:455–71.
Taku K, Calhoun LG, Tedeschi RG, et al. Examining posttraumatic growth among Japanese university students. Anxiety Stress Coping. 2007;20:353–67.
Bressoud A, Real del Sarte O, Stiefel S, et al. Impact of family structure on long-term survivors of osteosarcoma. Support Care Cancer. 2007;15:525–31.
Michel G, Taylor N, Absolom K, et al. Benefit finding in survivors of childhood cancer and their parents: further empirical support for the benefit finding scale for children. Child Care Health Dev. 2010;36:123–9.
Enneking WF, Dunham W, Gebhardt MC, et al. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241–6.
Davis AM, Wright JG, Williams JI, et al. Development of a measure of physical function for patients with bone and soft tissue sarcoma. Qual Life Res. 1996;5:508–16.
Marchese VG, Rai SN, Carlson CA, et al. Assessing functional mobility in survivors of lower-extremity sarcoma: reliability and validity of a new assessment tool. Pediatr Blood Cancer. 2007;49:183–9.
Wood-Dauphinee SL, Opzoomer MA, Williams JI, et al. Assessment of global function: the reintegration to normal living index. Arch Phys Med Rehabil. 1988;69:583–90.
Fukuhara S, Ware JE, Kosinski M, et al. Psychometric and clinical tests of validity of the Japanese SF-36 health survey. J Clin Epidemiol. 1998;51:1045–53.
Fekkes M, Kamphuis RP, Ottenkamp J, et al. Health-related quality of life in young adults with minor congenital heart disease. Psychol Health. 2001;16:239–50.
Theunissen NC, Vogels TG, Koopman HM, et al. The proxy problem: child report versus parent report in health-related quality of life research. Qual Life Res. 1998;7:387–97.
Bekkering WP, Billing L, Grimer RJ, et al. Translation and preliminary validation of the English version of the DUX questionnaire for lower extremity bone tumor patients (Bt-DUX): a disease-specific measure for quality of life. J Surg Oncol. 2013;107:353–9.
Koopman HM, Koetsier JA, Taminiau AH, et al. Health-related quality of life and coping strategies of children after treatment of a malignant bone tumor: a 5-year follow-up study. Pediatr Blood Cancer. 2005;45:694–9.
Nagarajan R, Mogil R, Neglia JP, et al. Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS). Cancer Surviv. 2009;3:59–65.
Ness KK, Leisenring WM, Huang S, et al. Predictors of inactive lifestyle among adult survivors of childhood cancer: a report from the childhood cancer survivor study. Cancer. 2009;115:1984–94.
Zahlten-Hinguranage A, Bernd L, Ewerbeck V, et al. Equal quality of life after limb-sparing or ablative surgery for lower extremity sarcomas. Br J Cancer. 2004;91:1012–4.
Forni C, Gaudenzi N, Zoli M, et al. Living with rotationplasty–quality of life in rotationplasty patients from childhood to adulthood. J Surg Oncol. 2012;105:331–6.
Veenstra KM, Sprangers MA, van der Eyken JW, et al. Quality of life in survivors with a Van Ness-Borggreve rotationplasty after bone tumour resection. Eur J Surg Oncol. 2000;73:192–7.
Acknowledgments
The authors thank Dr. Shin-ichiro Tatezaki and Dr. Kiyoko Kamibeppu, for their invaluable advice. The authors also thank the members of the Chiba Cancer Center and the Chiba Pediatric Orthopaedic Group (CPOG), for their encouragement.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Japan
About this chapter
Cite this chapter
Yonemoto, T., Iwata, S., Kamoda, H., Ishii, T. (2016). Long-Term Outcomes and Quality of Life (QOL) in Survivors of Pediatric and Adolescent Osteosarcoma. In: Ueda, T., Kawai, A. (eds) Osteosarcoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55696-1_20
Download citation
DOI: https://doi.org/10.1007/978-4-431-55696-1_20
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-55695-4
Online ISBN: 978-4-431-55696-1
eBook Packages: MedicineMedicine (R0)