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Lysophospholipid Mediators: Their Receptors and Synthetic Pathways

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Bioactive Lipid Mediators

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Abstract

It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. In addition, recent studies have identified several GPCRs for other lysophospholipids such as lysophosphatidylserine (LysoPS) and lysophosphatidylinositol (LPI). In this chapter, we summarize the actions and production of these LPLs as lipid mediators including LysoPS and LPI.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan

    Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu, Yuji Shinjo, Kahori Namiki, Hiroki Kawana, Saki Nemoto, Hirotaka Matsumoto, Ryoji Kise, Asuka Inoue & Junken Aoki

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  1. Kuniyuki Kano
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Correspondence to Junken Aoki .

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  1. Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Takehiko Yokomizo

  2. Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Makoto Murakami

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Kano, K. et al. (2015). Lysophospholipid Mediators: Their Receptors and Synthetic Pathways. In: Yokomizo, T., Murakami, M. (eds) Bioactive Lipid Mediators. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55669-5_8

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