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Lipid Mediators and Skin Diseases

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Bioactive Lipid Mediators

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Abstract

Lipid mediators, such as prostanoids and leukotrienes, are metabolites of arachidonic acid released in various pathophysiological conditions that exert a range of actions mediated through their respective receptors expressed on target cells. Although it has been difficult to analyze the physiological role of prostanoids or leukotrienes, recent developments in the disruption of both the respective genes and receptor-selective compounds have enabled us to investigate the physiological roles for lipid mediators. It has been demonstrated that each receptor of lipid mediators has multiple functions in a context-dependent manner, which sometimes results in opposite—excitatory and inhibitory—outcomes. The balance of the production and the receptor expression of each lipid mediator has been proved to be important for maintaining the homeostasis of our body. Here, we review new findings on the functions of prostanoids and leukotrienes in skin inflammatory diseases, focusing on contact dermatitis, atopic dermatitis, and psoriasis.

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Acknowledgments

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan

    Tetsuya Honda & Kenji Kabashima

  2. Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan

    Tetsuya Honda

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  1. Tetsuya Honda
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Correspondence to Kenji Kabashima .

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Editors and Affiliations

  1. Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Takehiko Yokomizo

  2. Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Makoto Murakami

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Honda, T., Kabashima, K. (2015). Lipid Mediators and Skin Diseases. In: Yokomizo, T., Murakami, M. (eds) Bioactive Lipid Mediators. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55669-5_21

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