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Lysophospholipid Acyltransferases

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Abstract

Glycerophospholipids are the main components of cellular membranes. Saturated (also monounsaturated) fatty acids and polyunsaturated fatty acids are usually esterified at the sn-1 and sn-2 position, respectively, in an asymmetrical manner. Using acyl-CoAs as donors, fatty acids of glycerophospholipids are regulated by lysophospholipid acyltransferases in a de novo pathway (Kennedy pathway) and a remodeling pathway (Lands’ cycle) to generate membrane diversity. Both pathways were reported in the 1950s. Fourteen lysophospholipid acyltransferases in the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) and membrane-bound O-acyltransferases (MBOAT) families have been identified to date. In this section, recent studies reporting the cloning and characterization of mammalian lysophospholipid acyltransferases are summarized.

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Acknowledgments

We are grateful to Prof. Takao Shimizu and all members of Shimizu’s laboratory (National Center for Global Health and Medicine, and The University of Tokyo) for their valuable suggestions.

Note

This work is supported by CREST, the Japan Science and Technology Agency (H.S.), a grant-in-aid for Scientific Research (C) (H.S.), and a Grant-in-Aid for Young Scientists (B) (D.H.) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.

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Authors and Affiliations

  1. Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan

    Hideo Shindou, Takeshi Harayama & Daisuke Hishikawa

  2. CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Hideo Shindou

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  1. Hideo Shindou
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  2. Takeshi Harayama
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  3. Daisuke Hishikawa
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Correspondence to Hideo Shindou .

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Editors and Affiliations

  1. Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Takehiko Yokomizo

  2. Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Makoto Murakami

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Shindou, H., Harayama, T., Hishikawa, D. (2015). Lysophospholipid Acyltransferases. In: Yokomizo, T., Murakami, M. (eds) Bioactive Lipid Mediators. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55669-5_1

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