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Common Pathways in IPF and Lung Cancer

Why Is Lung Cancer Highly Associated with IPF at a High Frequency?

  • Chapter
Idiopathic Pulmonary Fibrosis

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Abstract

Lung cancer which is the leading cause of cancer death worldwide leads to poor clinical outcome, similar to idiopathic pulmonary fibrosis (IPF). Lung cancer and IPF are often characterized by high comorbidity, and IPF is therefore considered to be a risk factor for the incidence of lung cancer. On the other hand, its high comorbidity recalls the existence of a common pathway in the pathogenesis and progression of both diseases. However, lung cancer and IPF have distinct phenotypes in the clinicopathological characteristics and therapeutic strategies. Rather, the standard of care for lung cancer with IPF has not yet been established, as treatments for lung cancer are sometimes harmful for comorbid IPF and induce its exacerbation that results in death. In order to pursue the answer to the question, “Why is lung cancer highly associated with IPF at a high frequency?” this chapter focused on the common pathogenesis of IPF and lung cancer and reviewed possible common pathways that are associated with both diseases. Besides common causative factors such as physical changes and environmental exposure, genetic modifications, epigenetic aberrations, and dysregulation in signaling pathways have indeed been reported as possible biological mechanisms that commonly underlie both diseases. Diverse common pathways as described in this chapter may account for the high frequency of lung cancer with IPF. The approach to a better understanding of these pathways will invite a novel perspective on therapeutics for this comorbidity, leading to an improved prognosis.

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  1. Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan

    Nobuyuki Koyama

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  1. Department of Respiratory Medicine, Tokyo Medical University, Ibaraki Medical Center , Ibaraki, Japan

    Hiroyuki Nakamura

  2. Department of Respiratory Medicine , Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan

    Kazutetsu Aoshiba

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Koyama, N. (2016). Common Pathways in IPF and Lung Cancer. In: Nakamura, H., Aoshiba, K. (eds) Idiopathic Pulmonary Fibrosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55582-7_14

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