Future Therapies in Medical Oncology



Antibodies to EGFR (cetuximab and panitumumab) and VEGF-A (bevacizumab) that are routinely used for treating metastatic colorectal cancer have failed to find a role in the management of localized rectal cancer. Other molecular targets worth considering include Her2/neu, BRAF, the PI3 kinase pathway, HSP90, and most recently the hypermutated phenotype of MSI tumors. Here we review selected trials using targeted agents in localized rectal cancer and propose other targeted strategies that have not yet been tested. In this era of molecular profiling, rectal cancer is an ideal opportunity to test the biological effects and clinical outcomes of preoperative molecularly targeted therapy.


Rectal Neoadjuvant Targeted therapy Immunotherapy Defective DNA repair 


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Copyright information

© Springer Japan 2018

Authors and Affiliations

  1. 1.Department of Medicine (Oncology)Stanford University Comprehensive Cancer CenterStanfordUSA
  2. 2.Department of Surgery (Colorectal)Stanford University Comprehensive Cancer CenterStanfordUSA

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