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Synthetic Strategies to Identify and Regulate Noncoding RNAs

  • Chapter
Long Noncoding RNAs

Abstract

RNA plays a central role in cell development and differentiation by regulating the flow of essential genetic information into the dynamic molecular machinery within the cell. Recently, large-scale sequencing techniques to analyze mammalian transcriptomes have substantiated the importance of the diverse population of the unannotated regions of the genome called noncoding RNAs (ncRNAs) in numerous biological processes and diseases. The ncRNAs demonstrate tissue-specific expression and sequence conservation across species. Therefore, ncRNAs are a highly desirable target for small-molecule modulators. However, therapeutic ncRNAs are considered “undruggable” because of the lack of understanding about the RNA secondary structural motifs, which are the preferred binding sites of small molecules. Strategies to design bioactive compounds based on the RNA secondary structure and sequence would enable researchers to develop novel therapeutic strategies and would aid the elucidation of the intricate translational machinery. In this chapter, we give a chemical perspective of ncRNAs and detail the synthetic strategies available to modulate novel RNA structures, which have been identified as therapeutic targets in disease and development.

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Authors and Affiliations

  1. Department of Chemistry, Graduate School of Science, Institute for Integrated Cell Material Sciences (WPI-iCeMS), Kyoto University, Sakyo, Kyoto, 606 8502, Japan

    Ganesh N. Pandian, Junetha Syed & Hiroshi Sugiyama

Authors
  1. Ganesh N. Pandian
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  2. Junetha Syed
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  3. Hiroshi Sugiyama
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Corresponding author

Correspondence to Hiroshi Sugiyama .

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Editors and Affiliations

  1. Division of Gene Structure and Function, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

    Riki Kurokawa

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© 2015 Springer Japan

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Pandian, G.N., Syed, J., Sugiyama, H. (2015). Synthetic Strategies to Identify and Regulate Noncoding RNAs. In: Kurokawa, R. (eds) Long Noncoding RNAs. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55576-6_2

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