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Coronary Angioscopy pp 217–227Cite as

Pharmacological Intervention

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Abstract

Ischemic heart disease is a life-threatening disorder; especially acute coronary syndrome (ACS) is a major cause of death in the world. Coronary arteries of angiographic significant stenosis with patients’ symptoms or certified myocardial ischemia are generally administered by revascularization therapies, such as coronary artery bypass surgery and percutaneous coronary intervention using balloon angioplasty or metallic stent deployment. However, ACS often arises from mild to moderate stenosis without the evidence of myocardial ischemia in a brief period. Accurate prospect of ACS is therefore complicated at the present, and pharmacological intervention as preventive insurance is extremely important. Among medical treatment for coronary risk factors, lipid-lowering therapy represented by administration of HMG-CoA reductase inhibitor (statin) is the most powerful, practical, and established way to prevent against ACS. From an angioscopic point of view, morphological changes in atherosclerotic coronary plaque focused on lipid-lowering intervention are reviewed in this chapter.

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Authors and Affiliations

  1. Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, Inzai, Chiba, 270-1694, Japan

    Masamichi Takano M.D., Ph.D.

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Correspondence to Masamichi Takano M.D., Ph.D. .

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Editors and Affiliations

  1. Mitsukoshi Health and Welfare Foundation, Nippon Medical School, Tokyo, Japan

    Kyoichi Mizuno

  2. Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan

    Masamichi Takano

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Takano, M. (2015). Pharmacological Intervention. In: Mizuno, K., Takano, M. (eds) Coronary Angioscopy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55546-9_19

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  • DOI: https://doi.org/10.1007/978-4-431-55546-9_19

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