Histopathologic Variations

  • Junzo Kigawa
  • Tsunehisa Kaku
  • Toru Sugiyama
  • Steven G. Silverberg


Histopathologic features of ovarian clear cell carcinoma (CCC) which are not in themselves diagnostic but are very common include the presence of oxyphil cells (prominent in 25–30 % of cases) and of endometriosis (found in the tumor-bearing ovary in 43 % of our cases, in most of which a direct origin of CCC could be demonstrated). The endometriosis was at least focally atypical in 69 % of the cases. Other findings in ovarian CCC which were either less specific and/or less common included signet ring cells, stromal inflammatory infiltrates/necrosis/cholesterol clefts/fibrosis, stromal edema or mucinous material, clefts around tumor cell nests, tumor multinodularity, thanatosomes, and foci of calcification with or without psammoma bodies and rarely ossification.


Mitotic Activity Histopathologic Feature Signet Ring Cell Clear Cell Carcinoma Cell Nest 
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  1. 1.
    LaGrenade A, Silverberg SG (1988) Ovarian tumors associated with atypical endometriosis. Hum Pathol 19:1080–1084CrossRefPubMedGoogle Scholar
  2. 2.
    Veras E, Mao TL, Ayhan A et al (2009) Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol 33:844–853CrossRefPubMedGoogle Scholar
  3. 3.
    Papadimitriou JC, Drachenberg CB, Brenner DS et al (2000) “Thanatosomes”. A unifying morphogenetic concept for tumor hyaline globules related to apoptosis. Hum Pathol 31:1455–1465CrossRefPubMedGoogle Scholar

Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Junzo Kigawa
    • 1
  • Tsunehisa Kaku
    • 2
  • Toru Sugiyama
    • 3
  • Steven G. Silverberg
    • 4
  1. 1.Matsue City HospitalMatsueJapan
  2. 2.Department of Health SciencesDepartment of Health Sciences Graduate School of Medical SciencesFukuokaJapan
  3. 3.Department of Obstetrics and GynecologyIwate Medical University School of MedicineMoriokaJapan
  4. 4.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA

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