Typical Histopathology

  • Junzo Kigawa
  • Tsunehisa Kaku
  • Toru Sugiyama
  • Steven G. Silverberg


Clear cell carcinoma (CCC) of the ovary is probably the single most recognizable type of ovarian carcinoma at the histopathologic level. Architecturally, the picture is one of micropapillary, tubulocystic, solid, or adenofibromatous patterns, or admixtures of two or more of these. Prominent stromal hyalinization is also a feature easily identifiable at low magnification. The dominant cells of ovarian CCC are characterized as either clear or hobnail cells, and again admixtures of the two cell types are common. One of the unique features of CCC is the presence (focally or diffusely) of bizarre nuclear atypia in the absence of prominent mitotic activity (almost all CCC having mitotic counts of less than 5 per 10 high-power fields).


Ovarian Carcinoma Ovarian Tumor Clear Cell Carcinoma Mitotic Count Stromal Invasion 
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  1. 1.
    Kobel M, Kalloger SE, Baker PM et al (2010) Diagnosis of ovarian carcinoma cell type is highly reproducible: a transcanadian study. Am J Surg Pathol 34:984–993CrossRefPubMedGoogle Scholar

Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Junzo Kigawa
    • 1
  • Tsunehisa Kaku
    • 2
  • Toru Sugiyama
    • 3
  • Steven G. Silverberg
    • 4
  1. 1.Matsue City HospitalMatsueJapan
  2. 2.Department of Health SciencesDepartment of Health Sciences Graduate School of Medical SciencesFukuokaJapan
  3. 3.Department of Obstetrics and GynecologyIwate Medical University School of MedicineMoriokaJapan
  4. 4.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA

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