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Electrochemical Biological Sensors Based on Directly Synthesized Carbon Nanotube Electrodes

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Frontiers of Graphene and Carbon Nanotubes
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Abstract

We have fabricated electrochemical biological sensors based on directly synthesized carbon nanotube (CNT) electrodes. Since CNTs have a large specific surface area, the direct synthesis of CNTs on electrodes in amperometric biosensors is expected to significantly enhance electroactive surface area. Moreover, in electrochemical detections, CNT electrodes promote electron-transfer reactions on CNT surfaces. In this section, we have investigated the technology and performance of the electrochemical biosensors based on CNT electrodes and described microfluidic chips with multibiosensors based on CNT electrodes for commercialization.

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References

  1. Leiner MJP (1991) Luminescence chemical sensors for biomedical applications: scope and limitations. Anal Chim Acta 255:209

    Article  Google Scholar 

  2. Muller KM, Arndt KM, Bauer K, Pluckthun A (1998) Tandem immobilized metal-ion affinity chromatography/immunoaffinity purification of His-tagged proteins--evaluation of two anti-His-tag monoclonal antibodies. Anal Biochem 259:54

    Article  Google Scholar 

  3. Lyon LA, Musick MD, Natan MJ (1998) Colloidal au-enhanced surface plasmon resonance immunosensing. Anal Chem 70:5177

    Article  Google Scholar 

  4. Drummond T, Hill M, Barton J (2003) Electrochemical DNA sensors. Nat Biotechnol 21:1192

    Article  Google Scholar 

  5. Stradiotto NR, Yamanaka H, Valnice M, Zanomi B (2003) Electrochemical sensors: a powerful tool in analytical chemistry. J Braz Chem Soc 14:159

    Article  Google Scholar 

  6. Bockrath M, Cobden DH, McEuen PL, Chopra NG, Zettl A, Thess A, Smalley RE (1997) Single-electron transport in ropes of carbon nanotubes. Science 275:1922

    Article  Google Scholar 

  7. Tans S, Verschueren A, Dekker C (1998) Room-temperature transistor based on a single carbon nanotube. Nature 393:49

    Article  Google Scholar 

  8. Star A, Gabriel J, Bradley K, Gruner G (2003) Electronic detection of specific protein binding using nanotube FET devices. Nano Lett 3:459

    Article  Google Scholar 

  9. Besteman K, Lee J, Wiertz F, Heering H, Dekker C (2003) Enzyme-coated carbon nanotubes as single-molecule biosensors. Nano Lett 3:727

    Article  Google Scholar 

  10. Maehashi K, Katsura T, Karman K, Matsumoto K, Tamiya E (2007) Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors. Anal Chem 79:782

    Article  Google Scholar 

  11. Katsura T, Yamamoto Y, Maehashi K, Ohno Y, Matsumoto K (2008) High-performance carbon nanotube field-effect transistors with local electrolyte gates. Jpn J Appl Phys 47:2060

    Article  Google Scholar 

  12. Maehashi K, Matsumoto K, Takamura Y, Tamiya E (2009) Aptamer-based label-free immunosensors using carbon nanotube field-effect transistors. Electroanalysis 21:1285

    Article  Google Scholar 

  13. Wang J (2004) Carbon-nanotube based electrochemical biosensors. Electroanalysis 17:7

    Article  Google Scholar 

  14. Liu G, Riechers SL, Mellen MC, Lin Y (2005) Sensitive electrochemical detection of enzymatically generated thiocholine at carbon nanotube modified glassy carbon electrode. Electrochem Commun 7:1163

    Article  Google Scholar 

  15. Fei S, Chen J, Yao S, Deng G, He D, Kuang Y (2005) Electrochemical behavior of L-cysteine and its detection at carbon nanotube electrode modified with platinum. Anal Biochem 339:29

    Article  Google Scholar 

  16. Lawrence NS, Wang J (2006) Chemical adsorption of phenothiazine dyes onto carbon nanotubes: Toward the low potential detection of NADH. Electrochem Commun 8:71

    Article  Google Scholar 

  17. Maehashi K, Ohno Y, Inoue K, Matsumoto K (2004) Chirality selection of single-walled carbon nanotubes by laser resonance chirality selection method. Appl Phys Lett 85:858

    Article  Google Scholar 

  18. Okuno J, Maehashi K, Matsumoto K, Kerman K, Takamura Y, Tamiya E (2007) Single-walled carbon nanotube-arrayed microelectrode chip for electrochemical analysis. Electrochem Commun 9:13

    Article  Google Scholar 

  19. Moreno L, Merkoci A, Alegret S, Cassou SH, Saurina J (2004) Analysis of amino acids in complex samples by using voltammetry and multivariate calibration methods Laura Morenoa. Anal Chim Acta 507:247

    Article  Google Scholar 

  20. Okuno J, Maehashi K, Kerman K, Matsumoto K, Takamura Y, Tamiya E (2007) Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes. Biosens Bioelectron 22:2377

    Article  Google Scholar 

  21. Manz A, Graber N, Widmer HM (1990) Miniaturized total chemical analysis sytems: a novel concept for chemical sensing. Sens Actuators B1:244

    Article  Google Scholar 

  22. Harrison DJ, Fluri K, Seiler K, Fan Z, Effenhauser CS, Manz A (1993) Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip. Science 261:895

    Article  Google Scholar 

  23. Reyes DR, Iossifidis D, Auroux P, Manz A (2002) Micro total analysis systems. 1. introduction, theory, and technology. Anal Chem 74:2623

    Article  Google Scholar 

  24. Tsujita Y, Maehashi K, Matsumoto K, Chikae M, Takamura Y, Tamiya E (2009) Microfluidic and label-free multi-immunosensors based on carbon nanotube microelectrodes. Jpn J Appl Phys 48:06FJ02

    Article  Google Scholar 

  25. Tsujita Y, Maehashi K, Matsumoto K, Chikae M, Torai S, Takamura Y, Tamiya E (2008) Carbon nanotube amperometric chips with pneumatic micropumps. Jpn J Appl Phys 47:2064

    Article  Google Scholar 

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Correspondence to Kenzo Maehashi .

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Maehashi, K., Matsumoto, K., Takamura, Y., Tamiya, E. (2015). Electrochemical Biological Sensors Based on Directly Synthesized Carbon Nanotube Electrodes. In: Matsumoto, K. (eds) Frontiers of Graphene and Carbon Nanotubes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55372-4_13

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  • DOI: https://doi.org/10.1007/978-4-431-55372-4_13

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55371-7

  • Online ISBN: 978-4-431-55372-4

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