Abstract
Adult T cell leukemia/lymphoma (ATL) is a highly invasive and intractable T cell malignancy caused by human T cell leukemia virus-1 infection. Leukemia/lymphoma cells that have invaded the tissues exhibit a propensity for strong resistance to chemotherapy, presenting a major obstacle to the treatment of ATL patients. Therefore, understanding how tissue-infiltrating leukemia/lymphoma cells acquire intractable features is important for developing effective treatments for ATL patients. We have recently found that, when co-cultured with epithelial-like feeder cells, ATL cells form anchorage-dependent multicellular aggregates and that a fraction of aggregate-forming ATL cells acquire quiescent CD44 high cancer stem cell-like phenotypes. This observation suggests that the intractability of tissue-infiltrating ATL cells may be partly accounted for by the acquisition of cancer stem cell-like properties.
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Acknowledgments
This work was supported in part by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT).
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The authors declare no competing financial interests.
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Miyatake, Y., Kasahara, M. (2015). Anchorage-Dependent Multicellular Aggregate Formation Induces CD44 High Cancer Stem Cell-Like Phenotypes in Adult T Cell Leukemia/Lymphoma Cells. In: Seya, T., Matsumoto, M., Udaka, K., Sato, N. (eds) Inflammation and Immunity in Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55327-4_6
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DOI: https://doi.org/10.1007/978-4-431-55327-4_6
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