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A New Mode of Cytotoxic T Lymphocyte Induction Secondary to Alteration of the Peptide/Major Histocompatibility Complex Class I Repertoire by Antigen Processing Defects

  • Takayuki Kanaseki
  • Yosuke Shionoya
  • Noriyuki Sato

Abstract

The cell surface repertoire of peptide/major histocompatibility complex (MHC) class I (pMHCI) provides potential ligands for circulating CD8+ cytotoxic T lymphocytes (CTLs). Because the action of antigen-processing machineries inside cells are necessary for optimizing pMHCI formation, it has been believed that antigen-processing defect (APD) attenuates any CTL responses. However, recent evidences demonstrate that the cells with APD often present a unique pMHCI repertoire harboring immunogenic peptides that are never displayed on normal cells. Here we focus on the absence of endoplasmic reticulum (ER)-resident editors ERAAP or tapasin and discuss a new mode of CTL induction secondary to it.

Keywords

MHC class I Antigen processing ERAAP Tapasin 

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Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Takayuki Kanaseki
    • 1
  • Yosuke Shionoya
    • 1
  • Noriyuki Sato
    • 2
  1. 1.Department of PathologySapporo Medical University School of MedicineSapporoJapan
  2. 2.School of MedicineSapporo Medical UniversitySapporoJapan

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