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A New Mode of Cytotoxic T Lymphocyte Induction Secondary to Alteration of the Peptide/Major Histocompatibility Complex Class I Repertoire by Antigen Processing Defects

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Inflammation and Immunity in Cancer

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Abstract

The cell surface repertoire of peptide/major histocompatibility complex (MHC) class I (pMHCI) provides potential ligands for circulating CD8+ cytotoxic T lymphocytes (CTLs). Because the action of antigen-processing machineries inside cells are necessary for optimizing pMHCI formation, it has been believed that antigen-processing defect (APD) attenuates any CTL responses. However, recent evidences demonstrate that the cells with APD often present a unique pMHCI repertoire harboring immunogenic peptides that are never displayed on normal cells. Here we focus on the absence of endoplasmic reticulum (ER)-resident editors ERAAP or tapasin and discuss a new mode of CTL induction secondary to it.

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Authors and Affiliations

  1. Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan

    Takayuki Kanaseki & Yosuke Shionoya

  2. School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan

    Noriyuki Sato

Authors
  1. Takayuki Kanaseki
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  2. Yosuke Shionoya
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  3. Noriyuki Sato
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Correspondence to Takayuki Kanaseki .

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Editors and Affiliations

  1. Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Tsukasa Seya

  2. Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Misako Matsumoto

  3. Kochi Medical School, Kochi University, Nankoku, Kochi, Japan

    Keiko Udaka

  4. School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan

    Noriyuki Sato

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Kanaseki, T., Shionoya, Y., Sato, N. (2015). A New Mode of Cytotoxic T Lymphocyte Induction Secondary to Alteration of the Peptide/Major Histocompatibility Complex Class I Repertoire by Antigen Processing Defects. In: Seya, T., Matsumoto, M., Udaka, K., Sato, N. (eds) Inflammation and Immunity in Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55327-4_16

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