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The Role of c-mip in the Pathogenesis of Minimal Change Nephrotic Syndrome

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Book cover Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

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Abstract

Although the molecular mechanisms underlying the pathophysiology of minimal change nephrotic syndrome (MCNS) remain unclear, clinical and experimental observations point to an immune origin. MCNS is currently considered as being caused by a putative circulating factor which increases glomerular permeability and leads to podocyte cytoskeleton disorganization and proteinuria. We recently identified c-mip (c-maf-inducing protein) as a key factor involved in lymphocyte and podocyte dysfunction observed in MCNS patients. The aim of this review is to describe recent findings about the potential role of c-mip into MCNS pathogenesis.

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Authors and Affiliations

  1. Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Hôpital Henri-Mondor, Assistance Publique–Hôpitaux de Paris (AP–HP), Université Paris-Est Créteil (UPEC), 51 avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France

    Vincent Audard & Dil Sahali

  2. INSERM U955, Equipe 21, Centre de Référence Syndrome Néphrotique Idiopathique, UPEC, 94000, Créteil, France

    Vincent Audard, André Pawlak & Dil Sahali

Authors
  1. Vincent Audard
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  2. André Pawlak
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  3. Dil Sahali
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Correspondence to Vincent Audard .

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Editors and Affiliations

  1. Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Osaka, Japan

    Kazunari Kaneko

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Audard, V., Pawlak, A., Sahali, D. (2016). The Role of c-mip in the Pathogenesis of Minimal Change Nephrotic Syndrome. In: Kaneko, K. (eds) Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55270-3_6

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  • DOI: https://doi.org/10.1007/978-4-431-55270-3_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55269-7

  • Online ISBN: 978-4-431-55270-3

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