Abstract
Beer is an alcoholic beverage that is made by yeast fermentation of the raw ingredients malt and hops. Since the mid-1990s, varieties of alcoholic beverages such as low-malt beer and no-malt brews made from soybean proteins or peptides instead of malt, and liquid sugar, have been launched. In the process of developing these alcohol beverages, a number of problems that have not previously been encountered in beer production have arisen. To solve these problems, therefore, it is necessary to investigate the physiological state of brewing yeast under various stressed conditions. In this chapter, we describe cellular responses to stress caused by different sugars, by nutrients other than sugars, and by mineral and vitamin deficiency, in addition to other environmental stresses that are predicted to be related to genes specific to bottom-fermenting yeast.
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References
Alper H, Moxley J, Nevoigt E et al (2006) Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 314:1564–1568
Alves SL Jr, Herbert RA, Hollatz C et al (2008) Molecular analysis of maltotriose active transport and fermentation by Saccharomyces cerevisiae reveals a determinant role for the AGT1 permease. Appl Environ Microbiol 74:1494–1501. doi:10.1128/AEM.02570-07
Bitterman KJ, Medvedik O, Sinclair DA (2003) Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev 67:376–399
Chen D, Guarente L (2006) SIR2: a potential target for calorie restriction mimetics. Trends Mol Med 13:64–71. doi:10.1016/j.molmed.2006.12.004
de Sousa HR, Spencer-Martins L, Goncalves P (2004) Differential regulation by glucose and fructose of a gene encoding a specific fructose/H+ symporter in Saccharomyces sense strict yeasts. Yeast 21:519–530. doi:10.1002/yea.1118
Dietvorst J, Londesborough J, Steensma HY (2005) Maltotriose utilization in lager yeast strains: MTT1 encodes a maltotriose transporter. Yeast 22:775–788. doi:10.1002/yea.1279
Diezemann A, Boles E (2003) Functional characterization of the Frt1 sugar transporter and of fructose uptake in Kluyveromyces lactis. Curr Genet 43:281–288. doi:10.1007/s00294-003-0392-5
Ding J, Huang X, Zhang L, Zhao N, Yang D, Zhang K (2009) Tolerance and stress response to ethanol in the yeast Saccharomyces cerevisiae. Appl Microbiol Biotechnol 85:253–263. doi:10.1007/s00253-009-2223-1
Du L, Su Y, Sun D et al (2008) Formic acid induces Yca1-iindependent apoptosis-like cell death in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 8:531–539. doi:10.1111/j.1567-1364.2008.00375.x
Eide DJ, Clark S, Nair TM et al (2005) Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae. Genome Biol 6:R77. doi:10.1186/gb-2005-6-9-r77
Goncalves P, Rodrigues de Sousa H, Spencer-Martins I (2000) FSY1, a novel gene encoding a specific fructose/H+ symporter in the type strain Saccharomyces carlsbergensis. J Bacteriol 182:5628–5630
Granot D, Snyder M (1991) Glucose induces cAMP-independent growth-regulated changes in stationary-phase cells of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88:5724–5728
Granot D, Snyder M (1993) Carbon source induces growth of stationary phase yeast cells, independent of carbon source metabolism. Yeast 9:465–479
Granot D, Levine A, Dor-Hefetz E (2003) Sugar-induced apoptosis in yeast cells. FEMS Yeast Res 4:7–13
Guaragnella N, Antonacci L, Passarella S et al (2011) Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways. Biochem Soc Trans 39:1538–1543. doi:10.1042/BST0391538
Hammond JRM (1993) Brewer’s yeasts. In: Rose AH, Harrison JS (eds) The yeasts, vol 5, 2nd edn. Academic, London, pp 7–67
Hatanaka H, Omura F, Kodama Y et al (2009) Gly-46 and His-50 of yeast maltose transporter Mal21p are essential fro its resistance against glucose-induced degradation. J Biol Chem 284:15448–15457. doi:10.1074/jbc.M808151200
Hohmann S, Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385:201–219
Jacobsen T, Lie S, Haga T (1981) Wort quality and the zinc content of malt. In: Proceedings of the 18th Congress European Brewers Convention, Copenhagen, pp 97–104
Jespersen L, Cesar D, Meaden PG et al (1999) Multiple α-glucoside transporter genes in brewer’s yeast. Appl Environ Microbiol 62:450–456
Kawakubo T, Iwasaki K, Tanaka M et al (2012) Effects of non-sugar nutrients concentration on fermentation and beer taste. In: Abstracts of the annual meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry 2012, Kyoto Women’s University, Kyoto, 23–25 March 2012
Lauff DB, Santa-Maria GE (2010) Potassium deprivation is sufficient to induce a cell death program in Saccharomyces cerevisiae. FEMS Yeast Res 10:497–507. doi:10.1111/j.1567-1364.2010.00628.x
Lee YJ, Burlet E, Galiano F et al (2011) Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast. J Biol Chem 286:20267–20274. doi:10.1074/jbc.M110.209379
Libkind D, Hittinger CT, Valerio E et al (2011) Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proc Natl Acad Sci U S A 108:14539–14544. doi:10.1073/pnas.115430108
Minato T, Yoshida S, Ishiguro T et al (2009) Expression profiling of the bottom fermenting yeast Saccharomyces pastorianus orthologous genes using oligonucleotide microarrays. Yeast 26:147–165. doi:10.1002/yea1654
Nakao Y, Kanamori T, Itoh T et al (2009) Genome sequence of the lager brewing yeast, an interspecies hybrid. DNA Res 16:115–129
Ness F, Aigle M (1995) RTM1: a member of a new family of telomeric repeated genes in yeast. Genetics 140:945–956
Ohsugi M, Imanishi Y (1985) Microbiological activity of biotin-vitamers. J Nutr Vitaminol (Tokyo) 31:563–572
Omura F, Hatanaka H, Nakao Y (2007) Characterization of a novel tyrosine permease of lager brewing yeast shared by Saccharomyces cerevisiae strain RM11-1a. FEMS Yeast Res 7:1350–1361. doi:10.1111/j.1567-1364.2007.00310.x
Pina C, Goncalves P, Prista C et al (2004) Ffz1, a new transporter specific for fructose from Zygosaccharomyces bailii. Microbiology 150:2429–2433. doi:10.1099/mic.0.26979-0
Piper P, Colderon CO, Hatzixanthis K et al (2001) Weak acid adaptation: the stress response that confers yeast with resistance to organic acid food preservatives. Microbiology 147:2635–2642
Saito H, Posas F (2012) Response to hyperosmotic stress. Genetics 192:289–318. doi:10.1534/genetics.112.140863
Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253–262
Suzuki T, Sugiyama M, Wakazono K et al (2012) Lactic-acid stress causes vacuolar fragmentation and impairs intracellular amino-acid homeostasis in Saccharomyces cerevisiae. J Biosci Bioeng 113:421–430. doi:10.1016/j.jbiosc.2011.11.010
Thevelein JM (1992) The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae. Antonie Van Leeuwenhoek 62:109–130
Watanabe D, Araki Y, Zhou Y et al (2012) A loss-of-function mutation in the PAS kinase Rim15p is related to defective quiescence entry and high fermentation rates of Saccharomyces cerevisiae sake yeast strains. Appl Environ Microbiol 78:4008–4016. doi:10.1128/AEM.00165-12
Yoshida S, Ikeda E, Uno I et al (1992) Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1. Mol Gen Genet 231:337–344
Yoshida S, Hashimoto K, Shimada E et al (2007a) Identification of bottom-fermenting yeast genes expressed during lager beer fermentation. Yeast 24:599–606. doi:10.1002/yea.1494
Yoshida S, Minato T, Ikado et al (2013) Nutrient stress response of bottom-fermenting yeast. In: Abstracts of the 65th annual meeting of the Society for Biotechnology Japan, International Conference Center Hiroshima, Hiroshima, 18–20 September 2013
Yoshimoto H, Ohuchi R, Ikado K et al (2009) Sugar induced death of the bottom fermenting yeast Saccharomyces pastorianus. J Biosci Bioeng 108:60–62. doi:10.1061/j.jbiosc.2008.12.022
Zastrow CR, Hollatz C, de Araujo PS et al (2001) Maltotriose fermentation by Saccharomyces cerevisiae. J Ind Microbiol Biotechnol 27:34–38
Zewail A, Xie MW, Xing Y et al (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A 100:3345–3350. doi:10.1073/pnas.0530118100
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Yoshida, S., Yoshimoto, H. (2015). Nutrient Stress Responses of the Bottom-Fermenting Yeast. In: Takagi, H., Kitagaki, H. (eds) Stress Biology of Yeasts and Fungi. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55248-2_8
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DOI: https://doi.org/10.1007/978-4-431-55248-2_8
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