Amebiasis pp 487-495 | Cite as

Human Genetic Susceptibility to Amebiasis

  • Shannon N. Moonah
  • Nona M. Jiang
  • William A. PetriJr.


One important unanswered question in amebic research is why only a proportion of individuals exposed to Entamoeba histolytica develop clinical disease. Variation in host genetic makeup is a key to explaining interindividual differences in susceptibility to amebiasis. In this chapter, we discuss the effects of a nonsynonymous polymorphism of the leptin receptor and HLA class II alleles in mediating resistance to amebiasis. In a prospective study on a cohort of preschool children living in Dhaka, Bangladesh, children with two copies of the ancestral Q223 allele in the leptin receptor were resistant to amebiasis. Children and mice with at least one copy of the leptin receptor 223R mutation were more susceptible to amebic colitis. HLA class II allele DQB1*0601 and the heterozygous haplotype DQB1*0601/DRB1*1501 were found to be protective against human intestinal amebiasis. An understanding of the human genes that underlie susceptibility to amebiasis could open new potential therapeutic and prophylactic pathways to the management of amebiasis.


Human Leukocyte Antigen Class Malnourished Child Entamoeba Histolytica Amebic Liver Abscess Amebic Colitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Shannon N. Moonah
    • 1
  • Nona M. Jiang
    • 1
  • William A. PetriJr.
    • 1
  1. 1.Division of Infectious Diseases and International Health, Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleUSA

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