Amebiasis pp 231-241 | Cite as

Transmembrane Kinases and Their Role in Entamoeba histolytica Pathogenesis

  • Nathaniel C. V. Christy
  • William A. PetriJr.


The transmembrane kinases (TMKs) of Entamoeba histolytica are a recently discovered family of cell-surface proteins that bear sequence similarity to the intermediate subunit of the Gal/GalNAc adherence lectin. The TMKs have been implicated in growth response to serum components as well as the phagocytosis of host cells and bacteria, processes that are critical to amebic pathogenesis during infection of the human host. Members of the TMK family appear to function variously as active kinases or pseudo-kinases depending on the structure of their intracellular domains and likely interact with intracellular signaling networks during signal transduction.


Epidermal Growth Factor Receptor Entamoeba Histolytica Histolytica Trophozoite Intracellular Kinase Domain Epidermal Growth Factor Receptor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Nathaniel C. V. Christy
    • 1
  • William A. PetriJr.
    • 1
  1. 1.Division of Infectious Diseases and International HealthUniversity of VirginiaCharlottesvilleUSA

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