Amebiasis pp 207-230 | Cite as

Signaling Pathways in Entamoeba histolytica

  • Saima Aslam
  • M. Shahid Mansuri
  • Alok Bhattacharya


A variety of functions in eukaryotes, such as cell migration, contraction, secretion, proliferation, differentiation, and exocytosis, are initiated and sustained by signaling processes. Most of the signalling pathways have been described in detail for many eukaryotic systems, particularly for mammalian systems. Signaling pathways quite often consist of cell-surface receptors, intracellular components that function as adaptors and transducers including those that generate second messengers leading to either alteration in gene expression or cytoskeleton dynamics. We have rudimentary knowledge about the organization of signaling systems in Entamoeba histolytica and the mechanisms by which initiation is coupled with functional readout, in spite of identification of a number of molecules known to participate in these pathways in other organisms. In this chapter we provide a summary of our current understanding on calcium and G-protein signaling pathways of E. histolytica and their role in different biological processes.


Guanine Nucleotide Exchange Factor Pleckstrin Homology Domain Cytoskeleton Dynamic Nicotinic Acid Adenine Dinucleotide Phosphate Actin Cytoskeleton Dynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Department of Biotechnology and BNP Paribas for financial support for carrying out some of the authors’ work described here. A.B. also thanks the Department of Science & Technology for the JC Bose Fellowship.


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Copyright information

© Springer Japan 2015

Authors and Affiliations

  • Saima Aslam
    • 1
  • M. Shahid Mansuri
    • 1
  • Alok Bhattacharya
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia

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