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Nanobiosensors and Nanobioanalyses pp 305–333Cite as

Plasmonic Sensors for Analysis of Proteins and an Oncologic Drug in Human Serum

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Abstract

Nanobiosensors exploiting the optical phenomenon of surface plasmon resonance (SPR) are ideal candidates for the design of optical sensors for clinical diagnostics. The label-free nature and sensitivity of SPR biosensors to binding events makes them generally applicable to the detection of a broad class of biomolecules. Recent advances in instrument design, surface chemistry, nanomaterials and biosensing strategies have enabled numerous applications of SPR biosensors. This chapter will explore in greater detail the challenges and solutions developed recently for the analysis of proteins and drugs in crude biofluids. Specifically, surface chemistry has been investigated thoroughly to minimize the interference of nonspecific adsorption from biofluids, while nanomaterials have been exploited to increase the sensitivity of SPR biosensors, with biosensing strategies involving nanoparticles allowing for the analysis of small molecules. Additionally, miniaturization and optimization of instrumental design have paved the way towards point-of-care diagnostics. The successful detection of biologically relevant molecules directly in biofluids relies on all of these recent advances. In this chapter, they will be contextualized for the analysis of proteins and an oncologic drug, methotrexate, in crude serum samples using SPR sensing.

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Authors and Affiliations

  1. Department of Chemistry, University of Montreal, Montreal, QC, Canada

    Jean-Francois Masson & Sandy Shuo Zhao

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  1. Jean-Francois Masson
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Correspondence to Jean-Francois Masson .

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  1. School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan

    Mun'delanji C. Vestergaard

  2. Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada

    Kagan Kerman

  3. Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR

    I-Ming Hsing

  4. Graduate School of Engineering, Osaka University, Osaka, Japan

    Eiichi Tamiya

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Masson, JF., Zhao, S.S. (2015). Plasmonic Sensors for Analysis of Proteins and an Oncologic Drug in Human Serum. In: Vestergaard, M., Kerman, K., Hsing, IM., Tamiya, E. (eds) Nanobiosensors and Nanobioanalyses. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55190-4_15

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