Abstract
Complexin (also called as synaphin), a small cytoplasmic protein, binds to SNAP receptor (SNARE) complex (membrane fusion machinery) and regulates neurotransmitter release at the post-priming stage. Several lines of evidence have demonstrated that complexin has at least two independent roles: clamping of the trans-SNARE complex and activation of Ca2+-triggered synchronous release of neurotransmitter. Both functions require its central SNARE binding domain. Recent studies suggest that complexin contains several functional domains that either stimulate or inhibit neurotransmitter release. Thus, the function of complexin is likely more complex than expected from its small size.
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Tokumaru, H. (2015). Regulation of SNAREs: Complexin. In: Mochida, S. (eds) Presynaptic Terminals. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55166-9_6
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DOI: https://doi.org/10.1007/978-4-431-55166-9_6
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