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Rapid Assembly of Cellular Aggregation Using Micro-Nano Technologies

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Engineered Cell Manipulation for Biomedical Application

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

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Abstract

A rapid construction process is necessary for building up numerous cellular aggregations into three-dimensional (3D) tissues that retain the tissue geometries and initial conditions of the cells. In this chapter, we introduce new 3D assembly techniques to fabricate different hollow tissue structures. In cellular self-assembly technique by using the micro-fabricated platform, we discuss a microlumen that facilitates the supply of oxygen and growth factors and the expulsion of waste products and then fabricate a toroid-like tissue by utilizing this assembly technique. In rapid assembly technique by using transfer printing, we discuss the relationship between the 3D transcriptional body of a gel matrix and the developed shape of transferred tissue and then fabricate a hollow tubular tissue by utilizing this assembly technique.

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Acknowledgment

This research was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology for Scientific Research (23106002 and 24106506) and the Nagoya University Global COE program for Education and the Research of Micro-Nano Mechatronics.

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Authors and Affiliations

  1. Department of Micro-Nano Systems Engineering, Graduate School of Engineering, Nagoya University, 1 Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan

    Taisuke Masuda Ph.D. & Fumihito Arai

Authors
  1. Taisuke Masuda Ph.D.
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  2. Fumihito Arai
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Corresponding author

Correspondence to Taisuke Masuda Ph.D. .

Editor information

Editors and Affiliations

  1. Osaka University, Osaka, Japan

    Misturu Akashi

  2. Osaka University, Osaka, Japan

    Takami Akagi

  3. Osaka University, Osaka, Japan

    Michiya Matsusaki

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© 2014 Springer Japan

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Masuda, T., Arai, F. (2014). Rapid Assembly of Cellular Aggregation Using Micro-Nano Technologies. In: Akashi, M., Akagi, T., Matsusaki, M. (eds) Engineered Cell Manipulation for Biomedical Application. Nanomedicine and Nanotoxicology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55139-3_2

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