Abstract
Ocular inflammation is known to be accompanied by retinal cell impairment. In uveitis, there are numerous causes of the retinal cell damage. However, secondary intraocular hypertension and direct inflammation caused by the uveitis are major concerns, as both of these can affect retinal cell survival. This is especially the case in sarcoidosis and Vogt–Koyanagi–Harada disease, which are the most common types of uveitis seen clinically in Japan. In addition, Behçet’s disease and acute retinal necrosis are also known to have a poor prognosis when patients are unable to receive precise treatments at specific time points during the clinical progress of the disease.
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References
Ohguro N, Sonoda KH, Takeuchi M, Matsumura M, Mochizuki M (2012) The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. Jpn J Ophthalmol 56:432–435
Newman LS, Rose CS, Maier LA (1997) Sarcoidosis. N Engl J Med 336:1224–1234
Hunninghake GW, Crystal RG (1981) Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 305:429–434
(1999) Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 160: 736–755 http://www.ncbi.nlm.nih.gov/pubmed/?term=Joint+Statement+of+the+American+Thoracic+Society+(ATS)%2C
Hiraga Y (1994) An epidemiological study of clustering of sarcoidosis cases. Nippon Rinsho 52:1438–1442
Hosoda Y, Hiraga Y, Odaka M et al (1976) A cooperative study of sarcoidosis in Asia and Africa: analytic epidemiology. Ann N Y Acad Sci 278:355–367
Ishige I, Usui Y, Takemura T, Eishi Y (1999) Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis. Lancet 354:120–123
McGrath DS, Goh N, Foley PJ, du Bois RM (2001) Sarcoidosis: genes and microbes–soil or seed? Sarcoidosis Vasc Diffuse Lung Dis 18:149–164
Lynch JP 3rd, Sharma OP, Baughman RP (1998) Extrapulmonary sarcoidosis. Semin Respir Infect 13:229–254
Crick RP, Hoyle C, Smellie H (1961) The Eyes in Sarcoidosis. Br J Ophthalmol 45:461–481
Ohara K, Okubo A, Sasaki H, Kamata K (1992) Intraocular manifestations of systemic sarcoidosis. Jpn J Ophthalmol 36:452–457
Jabs DA, Johns CJ (1986) Ocular involvement in chronic sarcoidosis. Am J Ophthalmol 102:297–301
Bonfioli AA, Orefice F (2005) Sarcoidosis. Semin Ophthalmol 20:177–182
Costabel U, Zaiss AW, Guzman J (1992) Sensitivity and specificity of BAL findings in sarcoidosis. Sarcoidosis 9(Suppl 1):211–214
Kojima K, Maruyama K, Inaba T et al (2012) The CD4/CD8 ratio in vitreous fluid is of high diagnostic value in sarcoidosis. Ophthalmology 119:2386–2392
Siltzbach LE, James DG, Neville E et al (1974) Course and prognosis of sarcoidosis around the world. Am J Med 57:847–852
Palestine AG, Nussenblatt RB, Chan CC (1986) Treatment of intraocular complications of sarcoidosis. Ann N Y Acad Sci 465:564–574
Nagata K, Maruyama K, Uno K et al (2012) Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis. Invest Ophthalmol Vis Sci 53:3827–3833
Forster DJ, Rao NA, Hill RA, Nguyen QH, Baerveldt G (1993) Incidence and management of glaucoma in Vogt-Koyanagi-Harada syndrome. Ophthalmology 100:613–618
Nowilaty SR, Bouhaimed M (2006) Photodynamic therapy for subfoveal choroidal neovascularisation in Vogt-Koyanagi-Harada disease. Br J Ophthalmol 90:982–986
Keino H, Goto H, Usui M (2002) Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation. Graefes Arch Clin Exp Ophthalmol 240:878–882
Mullaney J, Collum LM (1985) Ocular vasculitis in Behcet’s disease. A pathological and immunohistochemical study. Int Ophthalmol 7:183–191
Ahn JK, Yu HG, Chung H, Park YG (2006) Intraocular cytokine environment in active Behcet uveitis. Am J Ophthalmol 142:429–434
Masuda K, Nakajima A, Urayama A, Nakae K, Kogure M, Inaba G (1989) Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behcet’s disease. Lancet 1:1093–1096
Yazici H, Pazarli H, Barnes CG et al (1990) A controlled trial of azathioprine in Behcet’s syndrome. N Engl J Med 322:281–285
Whitcup SM, Salvo EC Jr, Nussenblatt RB (1994) Combined cyclosporine and corticosteroid therapy for sight-threatening uveitis in Behcet’s disease. Am J Ophthalmol 118:39–45
Okada AA, Goto H, Ohno S, Mochizuki M (2012) Multicenter study of infliximab for refractory uveoretinitis in Behcet disease. Arch Ophthalmol 130:592–598
Topilow HW, Nussbaum JJ, Freeman HM, Dickersin GR, Szyfelbein W (1982) Bilateral acute retinal necrosis. Clinical and ultrastructural study. Arch Ophthalmol 100:1901–1908
Culbertson WW, Blumenkranz MS, Haines H, Gass DM, Mitchell KB, Norton EW (1982) The acute retinal necrosis syndrome. Part 2: Histopathology and etiology. Ophthalmology 89:1317–1325
Ganatra JB, Chandler D, Santos C, Kuppermann B, Margolis TP (2000) Viral causes of the acute retinal necrosis syndrome. Am J Ophthalmol 129:166–172
Sugita S, Iwanaga Y, Kawaguchi T et al (2008) Detection of herpesvirus genome by multiplex polymerase chain reaction (PCR) and real-time PCR in ocular fluids of patients with acute retinal necrosis. Nihon Ganka Gakkai Zasshi 112:30–38
Sugita S, Shimizu N, Watanabe K et al (2008) Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthalmol 92:928–932
Holland GN (1994) Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. Am J Ophthalmol 117:663–667
Tawara A, Tou N, Kubota T, Harada Y, Yokota K (2008) Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. Graefes Arch Clin Exp Ophthalmol 246:1021–1028
Takahashi T, Ohtani S, Miyata K, Miyata N, Shirato S, Mochizuki M (2002) A clinical evaluation of uveitis-associated secondary glaucoma. Jpn J Ophthalmol 46:556–562
Miserocchi E, Waheed NK, Dios E et al (2002) Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparison. Ophthalmology 109:1532–1537
Zhang X, Clark AF, Yorio T (2008) FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest Ophthalmol Vis Sci 49:1037–1047
Steely HT, Browder SL, Julian MB, Miggans ST, Wilson KL, Clark AF (1992) The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells. Invest Ophthalmol Vis Sci 33:2242–2250
Benedikt O, Roll P (1979) The trabecular meshwork of a non-glaucomatous eye with the exfoliation syndrome. Electronmicroscopic study. Virchows Arch A Pathol Anat Histol 384:347–355
Rohen JW, Linner E, Witmer R (1973) Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid-glaucoma. Exp Eye Res 17:19–31
Roll P, Benedikt O (1979) Electronmicroscopic studies of the trabecular meshwork in corticosteroid glaucoma. Klin Monbl Augenheilkd 174:421–428
van Boxtel LA, van der Lelij A, van der Meer J, Los LI (2007) Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients. Ophthalmology 114:1358–1362
Kass MA, Becker B, Kolker AE (1973) Glaucomatocyclitic crisis and primary open-angle glaucoma. Am J Ophthalmol 75:668–673
Jap A, Sivakumar M, Chee SP (2001) Is Posner Schlossman syndrome benign? Ophthalmology 108:913–918
Chee SP, Bacsal K, Jap A, Se-Thoe SY, Cheng CL, Tan BH (2008) Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients. Am J Ophthalmol 145:834–840
Dinakaran S, Kayarkar V (2002) Trabeculectomy in the management of Posner-Schlossman syndrome. Ophthalmic Surg Lasers 33:321–322
Nakazawa T, Kayama M, Ryu M et al (2011) Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci 52:1384–1391
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Maruyama, K. (2014). Neuroinflammation. In: Nakazawa, T., Kitaoka, Y., Harada, T. (eds) Neuroprotection and Neuroregeneration for Retinal Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54965-9_20
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DOI: https://doi.org/10.1007/978-4-431-54965-9_20
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