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Neuroprotection and Neuroregeneration for Retinal Diseases pp 275–291Cite as

Neuroprotection for Retinal Detachment

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Abstract

Recent data have provided important clues about the molecular mechanisms underlying retinal neurodegenerative diseases, including retinal detachment (RD). Photoreceptor cell death causes various types of cell death such as apoptosis, necrosis, autophagy, and necroptosis. Apoptosis is the major type of photoreceptor death in RD and is the most defined type in experimental and clinical settings. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the “point of no return” of the lethal process. Modern medicine is developing an increasing number of treatments for neurodegenerative disease, but no neuroprotective treatment has yet been established for RD. This chapter briefly reviews the mechanisms of cell death and neuroprotection for RD.

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  1. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka City, 812-8582, Japan

    Toshio Hisatomi

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  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toru Nakazawa

  2. Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan

    Yasushi Kitaoka

  3. Visual Research Project, Tokyo Metropolitan Inst of Med Sci, Tokyo, Japan

    Takayuki Harada

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Hisatomi, T. (2014). Neuroprotection for Retinal Detachment. In: Nakazawa, T., Kitaoka, Y., Harada, T. (eds) Neuroprotection and Neuroregeneration for Retinal Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54965-9_19

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