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Aquaporin in Optic Neuropathies

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Neuroprotection and Neuroregeneration for Retinal Diseases

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Abstract

The aquaporins (AQPs) are plasma membrane water-transporting proteins. Many AQPs have been identified as playing essential roles in the nervous system and in ocular functions. The AQPs are potential drug targets for several neurological conditions. Additionally, recent evidence has demonstrated that some AQPs are involved in the pathophysiology of optic neuropathies. Notably, AQP4, a pure water channel expressed at astrocytes in the optic nerve, is the first target of neuromyelitis optica (NMO) in optic neuritis. AQP9 facilitates the transport of lactate for neural energy metabolism and may be considered an essential factor for retinal ganglion cell survival. This review summarizes the expression and known functions of the ocular AQPs related to optic neuropathies.

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Authors and Affiliations

  1. Division of Ophthalmology, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Akiyasu Kanamori

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  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toru Nakazawa

  2. Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan

    Yasushi Kitaoka

  3. Visual Research Project, Tokyo Metropolitan Inst of Med Sci, Tokyo, Japan

    Takayuki Harada

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Kanamori, A. (2014). Aquaporin in Optic Neuropathies. In: Nakazawa, T., Kitaoka, Y., Harada, T. (eds) Neuroprotection and Neuroregeneration for Retinal Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54965-9_12

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