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Oral Cancer pp 285–306Cite as

Radiotherapy

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Abstract

Radiotherapy has been used as a curative treatment for early-stage oral cavity cancer. Brachytherapy is performed by an experienced team, either alone or as a supplement to external beam radiation in selected small or superficial lesions. For more advanced lesions, a combined modality approach involving surgery followed by adjuvant radiation or chemoradiation has been performed. With the development of chemoradiotherapy in recent years, radiotherapy has been increasingly used as a radical treatment. However, the occurrence of adverse effects such as multiple caries and osteoradionecrosis after treatment is unavoidable. Intensity-modulated radiotherapy and particle beam radiation therapy have also been introduced for the treatment of oral cavity cancers. The accurate administration of doses to the tumor has become possible. Both can reduce normal tissue toxicities and can deliver high-dose radiation to the tumor. Therefore, better treatment results and reductions in late adverse events are expected. The role of chemoradiotherapy as a radical treatment is expected to progress along with chemotherapy. Intra-arterial chemoradiotherapy will be a particularly important modality for locally advanced oral cavity cancers.

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Notes

  1. 1.

    The particle beam doses are reported in gray equivalents (GyE), which are defined as the physical doses multiplied by the RBE of the protons or carbon ions. At HIBMC, the biological effects of both PBT and CIRT were evaluated in vitro and in vivo, and the RBE values for proton and carbon ion irradiation were determined to be 2–3.7 (depending on the SOBP depth) and 1.1, respectively [45].

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Authors and Affiliations

  1. Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan

    Kanako Takayama

  2. Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan

    Yusuke Demizu & Nobukazu Fuwa

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  1. Kanako Takayama
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  2. Yusuke Demizu
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  3. Nobukazu Fuwa
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Correspondence to Kanako Takayama .

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Editors and Affiliations

  1. Dept of Oral and Maxillofacial Surg, Nara Medical University, Kashihara, Nara, Japan

    Tadaaki Kirita

  2. Oral Cancer Center, Tokyo General Hospital, Tokyo, Tokyo, Japan

    Ken Omura

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Takayama, K., Demizu, Y., Fuwa, N. (2015). Radiotherapy. In: Kirita, T., Omura, K. (eds) Oral Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54938-3_11

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