Abstract
In several nonmammalian species natural regeneration occurs via dedifferentiation, where terminally differentiated cells revert back to a developmentally earlier stage. However, in mammals, once lost most terminally differentiated cells including cochlear hair cells do not regenerate. In this section, we introduce a novel strategy for hair cell regeneration in the mammalian inner ear, in which residual supporting cells are reprogrammed to otic progenitor cells that redifferentiate into hair cells. Induced pluripotent stem cell transcription factors (iPS cell TFs) and/or epigenetic modifications that intervene DNA methylation and histone acetylation are promising options to activate a cochlear supporting cell’s endogenous regenerative potential.
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Nishimura, K., Nakagawa, T. (2014). Dedifferentiation-Mediated Regeneration. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_22
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DOI: https://doi.org/10.1007/978-4-431-54862-1_22
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