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Dedifferentiation-Mediated Regeneration

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Abstract

In several nonmammalian species natural regeneration occurs via dedifferentiation, where terminally differentiated cells revert back to a developmentally earlier stage. However, in mammals, once lost most terminally differentiated cells including cochlear hair cells do not regenerate. In this section, we introduce a novel strategy for hair cell regeneration in the mammalian inner ear, in which residual supporting cells are reprogrammed to otic progenitor cells that redifferentiate into hair cells. Induced pluripotent stem cell transcription factors (iPS cell TFs) and/or epigenetic modifications that intervene DNA methylation and histone acetylation are promising options to activate a cochlear supporting cell’s endogenous regenerative potential.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Koji Nishimura & Takayuki Nakagawa

  2. Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

    Koji Nishimura

Authors
  1. Koji Nishimura
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  2. Takayuki Nakagawa
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Correspondence to Takayuki Nakagawa .

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Editors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Juichi Ito

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© 2014 Springer Japan

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Nishimura, K., Nakagawa, T. (2014). Dedifferentiation-Mediated Regeneration. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_22

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  • DOI: https://doi.org/10.1007/978-4-431-54862-1_22

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54861-4

  • Online ISBN: 978-4-431-54862-1

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