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Self-Repair

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Regenerative Medicine for the Inner Ear

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Abstract

Hair cells are known to be hard to regenerate in mammals once they are damaged. However, it is possible to repair even after damage, by blocking the degenerative pathway like an apoptosis. When hair cells are damaged, inflammatory responses are observed at first. At this stage, anti-inflammatory drugs such as glucocorticoid or cytokines are effective against hair cell damage. Also hair cells have proceeded to damage, mainly through a process known as apoptosis. During this process, anti-apoptotic drugs are effective for hair cell repair. Anti-reactive oxygen species (ROS), c-Jun-N-Terminal kinases (JNK) inhibitor, or caspase inhibitors are considered to be protective effect against hair cell damage. Neurotrophic factors and growth factors might be also effective for hair cells.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Akiko Taura & Takayuki Nakagawa

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  1. Akiko Taura
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  2. Takayuki Nakagawa
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Correspondence to Akiko Taura .

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  1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Juichi Ito

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Taura, A., Nakagawa, T. (2014). Self-Repair. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_20

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  • DOI: https://doi.org/10.1007/978-4-431-54862-1_20

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