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Regenerative Medicine for the Inner Ear pp 101–113Cite as

Cochlear Development

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Abstract

The sensory epithelium of the cochlear duct, called the organ of Corti, is the hearing organ of mammals including human. The organ of Corti is a masterpiece of cellular micro-architecture. The organ of Corti consists of two subtypes of hair cells, a single row of inner and three rows of outer hair cells, and several subtypes of supporting cells strategically positioned on the basilar membrane. The organization of these cells maximizes the extraction of sound energy by amplifying sound-induced basilar membrane motion and transmitting those movements, via the help of the tectorial membrane, to inner hair cells. In this section, an overview of cochlear development is presented and four important events during cochlear development are described: extension of cochlear duct, prosensory specification, cell-cycle exit, and cellular differentiation. Some of the most recent and enlightening results regarding the molecular mechanism underlying the formation of the organ of Corti are also discussed. Most data are from the experiments using mice, the most comprehensive model system for the developing mammalian cochlea.

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Authors and Affiliations

  1. Institute for Virus Research, Kyoto University, Kyoto, 606-8507, Japan

    Tomoko Tateya

  2. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Tomoko Tateya

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  1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Juichi Ito

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Tateya, T. (2014). Cochlear Development. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_12

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