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Development and Regeneration

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Book cover Regenerative Medicine for the Inner Ear

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Abstract

Currently, regeneration of target organs is achieved by several strategies, including transplantation of stem cells and reprogramming of mature cells to the desired cell types (transdifferentiation). Transplantation of naïve stem cells can cause several problems such as teratoma formation, immunogenicity, and elimination of transplanted cells. These disadvantages can be avoided by induction of stem cells into the desired cell types. On the other hand, transdifferentiation of mature cells into the desired mature or differentiating cell types is another viable option for circumventing the numerous negative adverse effects of naïve stem cell transplantation. The selection of most of the factors required for the induction of stem cells or transdifferentiation is based on the progressively accumulating knowledge of developmental biology. These aspects include the determinants of dorsoventral or anteroposterior axis and germinal layers or the transcription factors specific for desired organs. By manipulating pluripotent stem cells using predetermined factors, these stem cells can be induced into all three germ layers (endoderm, mesoderm, and ectoderm) and into differentiated organs. To date, several organs have been successfully transdifferentiated from other types of mature cells.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Norio Yamamoto

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  1. Norio Yamamoto
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Correspondence to Norio Yamamoto .

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  1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Juichi Ito

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Yamamoto, N. (2014). Development and Regeneration. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_10

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  • DOI: https://doi.org/10.1007/978-4-431-54862-1_10

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  • Print ISBN: 978-4-431-54861-4

  • Online ISBN: 978-4-431-54862-1

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