Skip to main content
SpringerLink
Log in
Book cover

Regenerative Medicine in Otolaryngology pp 87–105Cite as

Development and Regeneration of the Nose and the Paranasal Sinuses

  • Chapter

  • 951 Accesses

Abstract

In the first section of this chapter, nasal embryology is described. An understanding of nasal embryology and anatomy is of considerable importance for regenerative medicine of the nose. Most of the components of the nasal and paranasal sinuses arise from the ectodermal germ layer. During the fifth embryonic week, nasal development starts from a small pit, which subsequently deepens to form a cavity. Formation of the soft and hard palate, and fusion of the nasal septum and the palate are completed in the twelfth embryonic week. Differentiation of the nasal respiratory epithelium is almost finished by the twenty-fourth embryonic week. In the second section of this chapter, progress in tissue engineering techniques for nasal reconstruction is summarized. Tissue engineering of the mucosa, cartilage, bone, and skin is essential for complete nasal reconstruction. The final section describes the use of regenerative medicine in restoring olfactory function. The olfactory system has a high intrinsic regenerative capacity; however, many patients experience olfactory disorders. Recent advances in the field of olfactory regenerative medicine are explained.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Sadler TW. Langman’s medical embryology. 12th ed. Philadelphia: Lippincott William & Wilkins; 2012.

    Google Scholar 

  2. Moore KL, Persaud TVN, Torchia MG. The developing human. 9th ed. Philadelphia: Saunders; 2011.

    Google Scholar 

  3. Zimbler MS. Gaspare Tagliacozzi: renaissance surgeon. Arch Facial Plast Surg. 2001;3:283–4.

    Article  CAS  PubMed  Google Scholar 

  4. Moharamzadeh K, Brook IM, Van NR, et al. Development, optimization and characterization of a full-thickness tissue engineered human oral mucosal model for biological assessment of dental biomaterials. J Mater Sci Mater Med. 2008;19:1793–801.

    Article  CAS  PubMed  Google Scholar 

  5. Heikal MY, Aminuddin BS, Jeevanan J, et al. A scanning electron microscopic study of in vivo tissue engineered respiratory epithelium in sheep. Med J Malaysia. 2008;63 suppl A:34.

    PubMed  Google Scholar 

  6. Huang TW, Young YH, Cheng PW, et al. Culture of nasal epithelial cells using chitosan-based membranes. Laryngoscope. 2009;119:2066–70.

    Article  CAS  PubMed  Google Scholar 

  7. Kannan RY, Salacinski HJ, Butler PE, et al. Polyhedral oligomeric silsesquioxane nanocomposites: the next generation material for biomedical applications. Acc Chem Res. 2005;38:879–84.

    Article  CAS  PubMed  Google Scholar 

  8. Vinatier C, Mrugala D, Jorgensen C, et al. Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol. 2009;27:307–14.

    Article  CAS  PubMed  Google Scholar 

  9. Francioli SE, Candrian C, Martin K, et al. Effect of three-dimensional expansion and cell seeding density on the cartilage-forming capacity of human articular chondrocytes in type II collagen sponges. J Biomed Mater Res A. 2010;95:924–31.

    Article  PubMed  Google Scholar 

  10. Raghunath J, Salacinski HJ, Sales KM, et al. Advancing cartilage tissue engineering: the application of stem cell technology. Curr Opin Biotechnol. 2005;16:503–9.

    Article  CAS  PubMed  Google Scholar 

  11. Nussbaum J, Minami E, Laflamme MA, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J. 2007;21:1345–57.

    Article  CAS  PubMed  Google Scholar 

  12. Breitbach M, Bostani T, Roell W, et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood. 2007;110:1362–9.

    Article  CAS  PubMed  Google Scholar 

  13. Yanaga H, Imai K, Yanaga K. Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation. Aesthetic Plast Surg. 2009;36:765–802.

    Google Scholar 

  14. Umeda H, Kanemaru S. Bone regeneration of canine skull using bone marrow-derived stromal cells and beta-tricalcium phosphate. Laryngoscope. 2007;117(6):997–1003.

    Article  CAS  PubMed  Google Scholar 

  15. Umeda H, Kanemaru S. In situ tissue engineering of canine skull with guided bone regeneration. Acta Otolaryngol. 2009;129(12):1509–18.

    Article  CAS  PubMed  Google Scholar 

  16. De LM, Albanese E, Bondanza S, et al. Multicentre experience in the treatment of burns with autologous and allogenic cultured epithelium, fresh or preserved in a frozen state. Burns. 1989;15:303–9.

    Article  Google Scholar 

  17. Compton CC, Gill JM, Bradford DA, et al. Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. A light, electron microscopic and immunohistochemical study. Lab Invest. 1989;60:600–12.

    CAS  PubMed  Google Scholar 

  18. Groeber F, Holeiter M, Hampel M, et al. Skin tissue engineering – in vivo and in vitro applications. Adv Drug Deliv Rev. 2011;63:352–66.

    Article  CAS  PubMed  Google Scholar 

  19. Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991;65(1):175–87.

    Article  CAS  PubMed  Google Scholar 

  20. Duncan HJ, et al. Long-term follow up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolaryngol Head Neck Surg. 1995;121:1183–7.

    Google Scholar 

  21. Uraih LC, Maronpot RR. Normal histology of the nasal cavity and application of special techniques. Environ Health Perspect. 1990;85:187–208.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Barnett SC, Riddell JS. Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats. J Anat. 2004;204(1):57–67.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Beites CL, Calof AL, et al. Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res. 2005;306:309–16.

    Article  CAS  PubMed  Google Scholar 

  24. Ikeda K. Two distinct neurogenesis in the olfactory epithelium. Jpn Assoc Study Taste Smell. 2012;19(1):63–9.

    CAS  Google Scholar 

  25. Ikeda K, Kawakami K, et al. Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54:1453–64.

    Article  PubMed  Google Scholar 

  26. Cau E, Casarosa S, Guillemot F. Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development. 2002;129:1871–80.

    CAS  PubMed  Google Scholar 

  27. Oboti L, et al. From chemical neuroanatomy to an understanding of the olfactory system. Eur J Histochemistory. 2011;55:e35.

    Article  CAS  Google Scholar 

  28. Kobayashi M, Majima Y, et al. Safety and usefulness of the long-term intranasal topical treatment with steroids for olfactory dysfunction. Nihon Jibiinkoka Gakkai Kaiho. 2005;108(10):986–95.

    Article  PubMed  Google Scholar 

  29. Miwa T, et al. The effectiveness of Toki-Syakuyaku-san for the olfactory disturbed patients. Jpn Assoc Study Taste Smell. 2005;12(3):523–4.

    Google Scholar 

  30. Yasuno H, Noguchi K, et al. Nerve growth factor applied onto the olfactory epithelium alleviates degenerative changes of the olfactory receptor neurons following axotomy. Brain Res. 2000;887(1):53–62.

    Article  CAS  PubMed  Google Scholar 

  31. Nishikawa T, Doi K, Nibu K, et al. Effect of intranasal administration of basic fibroblast growth factor on olfactory epithelium. Neuroreport. 2009;20(8):764–9.

    Article  CAS  PubMed  Google Scholar 

  32. Kern RC, Conley DB, Haines 3rd GK, Robinson AM. Treatment of olfactory dysfunction, II: studies with minocycline. Laryngoscope. 2004;114(12):2200–4.

    Article  CAS  PubMed  Google Scholar 

  33. Kobayashi M, Takeuchi K, et al. Blockade of interleukin-6 receptor suppresses inflammatory reaction and facilitates functional recovery following olfactory system injury. Neurosci Res. 2013;76:125–32.

    Article  CAS  PubMed  Google Scholar 

  34. Costanzo RM, Yagi S. Olfactory epithelial transplantation: possible mechanism for restoration of smell. Curr Opin Otolaryngol Head Neck Surg. 2011;19(1):54–7.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Goldstein BJ, Schwob JE. Transplantation of multipotent progenitors from the adult olfactory epithelium. Neuroreport. 1998;9:1611–7.

    Article  CAS  PubMed  Google Scholar 

  36. Jang W, Schwob JE, et al. Maintaining epitheliopoietic potency when culturing olfactory progenitors. Exp Neurol. 2008;214(1):25–36.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology – Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Atsushi Suehiro & Toshio Ueda

Authors
  1. Atsushi Suehiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshio Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Atsushi Suehiro .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Kyoto University, Kyoto, Japan

    Juichi Ito

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Japan

About this chapter

Cite this chapter

Suehiro, A., Ueda, T. (2015). Development and Regeneration of the Nose and the Paranasal Sinuses. In: Ito, J. (eds) Regenerative Medicine in Otolaryngology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54856-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54856-0_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54855-3

  • Online ISBN: 978-4-431-54856-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation