Abstract
The aim of this study is to establish a regenerative treatment for soft tissue defects of the external auditory meatus (EAM) without conventional surgical therapy. Thirty patients with new or old EAM defects without active inflammation were randomly selected. Ages ranged from 15 to 82 (average age of 55). Gelatin sponge, basic fibroblast growth factor (b-FGF), fibrin glue, and waterproof transparent dressing were used in the repair procedure. Patients were divided into two groups: treatment with (n = 20) and without (n = 10) b-FGF. After mechanically disrupting the edge of the EAM defect, gelatin sponge immersed in b-FGF was placed over the defect and covered with fibrin glue. In cases of extensive EAM defects, the EAM was filled with gelatin sponge/b-FGF, and the auricle was wrapped in waterproof dressing. Three weeks post-procedure, crust over the defect was removed. If complete defect closure was not achieved after one treatment course, the treatment was repeated until three times. Evaluation of complete closure of EAM defects was performed 3 months posttreatment. Complete closure of the EAM defect was achieved within three treatment courses in 90 % (18/20) and 20 % (2/10) of the patients with or without b-FGF, respectively. No inflammation/infection or severe sequelae were observed.
This study demonstrated the effectiveness of combining gelatin sponge, b-FGF, and fibrin glue for EAM defect regeneration. This innovative regenerative therapy is an easy, simple, cost-effective, and minimally invasive method for treating EAM defects.
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Kanemaru, Si. (2015). Regeneration of the Soft Tissue Defects of the External Auditory Meatus. In: Ito, J. (eds) Regenerative Medicine in Otolaryngology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54856-0_3
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DOI: https://doi.org/10.1007/978-4-431-54856-0_3
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