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Regenerative Medicine in Otolaryngology pp 209–223Cite as

Salivary Gland Development and Regeneration

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Abstract

Salivary glands are required for oral health and general well-being. In patients suffering from irreversible salivary hypofunction secondary to therapeutic radiation exposure or Sjögren’s syndrome, available therapies are limited to salivary gland substitutes or parasympathetic stimulants, both of which show limited efficacy. The pathophysiologic basis of radiation-induced damage involves a reduction in viable acinar cells required for physiologic function, as well as a deterioration in acinar cell morphology. Together, these alterations lead to irreversible salivary gland dysfunction. Therefore, it is imperative to prevent damage to these acinar cells and to recover lost function of those cells after exposure to radiation. This chapter provides a brief overview of the current strategies being implemented for the prevention of radiation-induced damage, current strategies for the regeneration of acinar cells, and concludes with a basic review of salivary gland anatomy and development.

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Authors and Affiliations

  1. Department of Otolaryngology, Tenri Hospital, 200 Mishima-cho, Tenri-shi, Nara, 632-8552, Japan

    Tsuyoshi Kojima MD, PhD

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  1. Tsuyoshi Kojima MD, PhD
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Correspondence to Tsuyoshi Kojima MD, PhD .

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Editors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Kyoto University, Kyoto, Japan

    Juichi Ito

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Kojima, T. (2015). Salivary Gland Development and Regeneration. In: Ito, J. (eds) Regenerative Medicine in Otolaryngology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54856-0_14

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  • DOI: https://doi.org/10.1007/978-4-431-54856-0_14

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54855-3

  • Online ISBN: 978-4-431-54856-0

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